Reproducibility of Central Corneal Thickness Measurements in Normal Eyes Using the Zeiss Cirrus 5000 HD-OCT and Pentacam HR.

IF 0.4 Q4 OPHTHALMOLOGY Open Ophthalmology Journal Pub Date : 2018-05-18 eCollection Date: 2018-01-01 DOI:10.2174/1874364101812010072

Elmira Baghdasaryan, Xiwen Huang, Kenneth M Marion, Tudor C Tepelus, Homayoun Bagherinia, SriniVas R Sadda, Hugo Y Hsu

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引用次数: 13

Abstract

Objectives: To determine the repeatability and reproducibility of Central Corneal Thickness (CCT) measurements using two different anterior segment imaging modalities, including those obtained with the new anterior segment lens attachments for the Cirrus 5000 HD-OCT.

Methods: A total of 32 eyes from 16 normal volunteers (8 male, 8 female) were enrolled in this prospective study. CCT was measured by the same examiner using the Cirrus 5000 HD-OCT and Pentacam HR. The results of CCT obtained by each method were averaged and compared using t-test analysis. The agreement between the measurement methods was evaluated. Coefficient of Repeatability (CoR) and Intra-Class Correlation Coefficient (ICC) were computed.

Results: The mean measurements taken with the Cirrus OCT anterior chamber lens (CCT_AC), HD cornea lens (CCT_HDC) and pachymetry scans (CCT_Pach) were 545.35 ± 31.02, 537.87 ± 26.82, and 532.04 ± 29.82 µm, respectively. The mean CCT obtained with the Pentacam (CCT_Pent) was 545.51 ± 30.71 µm. CCT_Pent were significantly higher than CCT_HDC and CCT_Pach (p< 0.0001). In contrast, the CCT_Pent and CCT_AC were similar (p=0.87). CCT, as evaluated by the two different instruments, showed excellent correlation (r > 0.98, p< 0.0001) with an ICC > 0.99 (95% CI, 0.97 - 0.99). CoR was the highest for CCT_Pach (3.7 ± 1.4, 95% CI (3.0- 4.6)).

Conclusion: CCT measurements from the Cirrus OCT using the new anterior segment lens attachments and the Pentacam HR are highly correlated. This should allow the use of a standardized correction factor if necessary to inter-relate the measurements between the two devices.

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使用蔡司Cirrus 5000 HD-OCT和Pentacam HR测量正常眼睛中央角膜厚度的可重复性。

目的:确定使用两种不同的前节成像方式测量角膜中央厚度(CCT)的可重复性和再现性，包括使用Cirrus 5000 HD-OCT的新型前节晶状体附件获得的结果。方法:对16名正常志愿者(男8名，女8名)共32只眼进行前瞻性研究。CCT由同一审查员使用Cirrus 5000 HD-OCT和Pentacam HR测量。各方法CCT结果取平均，采用t检验分析比较。评估了测量方法之间的一致性。计算重复性系数(CoR)和类内相关系数(ICC)。结果:Cirrus OCT前房晶状体(CCTAC)、HD角膜晶状体(CCTHDC)和角膜测量仪(CCTPach)的平均测量值分别为545.35±31.02、537.87±26.82和532.04±29.82µm。Pentacam获得的CCT平均值为545.51±30.71µm。CCTPent显著高于CCTHDC和CCTPach (p< 0.0001)。相比之下，CCTPent和CCTAC相似(p=0.87)。通过两种不同的仪器评估，CCT显示出良好的相关性(r > 0.98, p< 0.0001)， ICC > 0.99 (95% CI, 0.97 - 0.99)。CCTPach组CoR最高(3.7±1.4,95% CI(3.0- 4.6))。结论:使用新的前段晶状体附着体的Cirrus OCT的CCT测量与Pentacam HR高度相关。如果有必要，这应该允许使用标准化校正因子来相互关联两个设备之间的测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Open Ophthalmology Journal OPHTHALMOLOGY-

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0.50

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0.00%

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期刊介绍： The Open Ophthalmology Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in ophthalmology, including use of ophthalmological therapies, devices and surgical techniques. The Open Ophthalmology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and making them freely available to researchers worldwide.