PREOXYGENATION: COULD SAFETY MEASURE BE MADE LESS DANGEROUS?.

L U Kamenskaya, K M Lebedinskiy
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Abstract

While providing reserve time for dificult airway management, preoxygenation with pure oxygen increases the risk of pulmonary complications due to absorption atelectases. The authors explored when it could be appropriate to prevent atelectases by preoxygenation with decreased FiO₂. ASA I-II elective gynecological surgery patients were randomized among five groups (n = 22 each) with preoxygenation using FiO₂ 100, 70, 60, 60% + PEEP 5 mbar and 50%. Even FiO₂ 70% led to decrease. in safe apnea time (i.e. time interval to Sp²O₂ 95%) by two, while FiO₂ 50% - by more than three times. Furthermore, in five similar additional groups of women with same techniques ofpreoxygenation (n = 10 each) it was shown that for FiO₂ 5 70% very fast pattern of SpO2 fall after the first change ofpulseoxymeter figure (100% by 99%) is typical: interval to SpO2 90% was less than 1 min, while for FiO₂ 100% it lasts for 200 s. Since critical problem is "Cannot intubate, cannot ventilate", the authors tried to focus on the difficultfacemask ventilation prognosis. In the group of 71 elective general surgery patients (31 males, 40 females, ASA I-III) original prognostic model based on seven simple bedside tests (removable dentures, beard, snoring, Mallampati class 2-4, age > 50 y.o., BM > 30 kg/m², sternomental distance < 12 cm) demonstrated the reliability of difficult facemask ventilation negative prognosis of 97,5%. The authors suggest that only in patients with reliable prognosis of easy facemask ventilation prevention ofpulmonary complications by preoxygenation with FiO₂ 50-60% could be safely recommended.

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预充氧:安全措施能降低危险性吗?
在为困难气道管理提供储备时间的同时,纯氧预充氧增加了因吸收不张引起的肺部并发症的风险。作者探讨了通过减少FiO₂预充氧来预防肺不张酶的合适时机。ASA I-II期择期妇科手术患者随机分为5组,每组22例,分别采用FiO₂100、70、60、60% + PEEP 5 mbar和50%预充氧。即使FiO₂70%也会导致下降。安全呼吸时间(即至Sp²O₂95%的时间间隔)缩短两倍,而FiO₂50%缩短三倍以上。此外,在另外五组采用相同预充氧技术的女性中(每组10人),结果表明,在脉搏氧计数值第一次变化(100% × 99%)后,FiO 2 70%的SpO2下降非常快的模式是典型的:间隔到SpO2 90%不到1分钟,而FiO 2 100%持续200秒。由于“不能插管,不能通气”是关键问题,笔者试图着重探讨面罩通气困难的预后。在71例择期普通外科患者(男31例,女40例,ASA I-III)中,基于7项简单床边试验(可摘义齿、beard、鼾症、Mallampati 2-4级、年龄> 50岁、BM > 30 kg/m²、胸骨距离< 12 cm)的原始预后模型显示面罩通气困难阴性预后的可靠性为97.5%。作者认为,只有在预后可靠的简易面罩通气患者中,才可以安全地推荐FiO₂预充氧50-60%以预防肺部并发症。
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