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{"title":"Exploring the Genetic Landscape of Metabolic Phenotypes with MetaboSignal","authors":"Andrea Rodriguez-Martinez, Rafael Ayala, Joram M. Posma, Marc-Emmanuel Dumas","doi":"10.1002/cpbi.41","DOIUrl":null,"url":null,"abstract":"<p>MetaboSignal is an R/Bioconductor package designed to explore the relationships between genes and metabolites, using the Kyoto Encyclopedia of Genes and Genomes (KEGG) as its primary database. It is a network-based approach that allows overlaying metabolic and signaling pathways and exploring the topological relationship between genes (signaling or metabolic genes) and metabolites. MetaboSignal is ideally suited to identify candidate genes in metabolome genome-wide association studies (mGWAS), particularly in the case of <i>trans</i>-acting associations. It can also be used to provide mechanistic explanations of perturbed metabolic patterns observed in genetic models, as well as to identify novel target metabolic pathways of signaling genes. © 2018 by John Wiley & Sons, Inc.</p>","PeriodicalId":10958,"journal":{"name":"Current protocols in bioinformatics","volume":"61 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cpbi.41","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current protocols in bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cpbi.41","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
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Abstract
MetaboSignal is an R/Bioconductor package designed to explore the relationships between genes and metabolites, using the Kyoto Encyclopedia of Genes and Genomes (KEGG) as its primary database. It is a network-based approach that allows overlaying metabolic and signaling pathways and exploring the topological relationship between genes (signaling or metabolic genes) and metabolites. MetaboSignal is ideally suited to identify candidate genes in metabolome genome-wide association studies (mGWAS), particularly in the case of trans -acting associations. It can also be used to provide mechanistic explanations of perturbed metabolic patterns observed in genetic models, as well as to identify novel target metabolic pathways of signaling genes. © 2018 by John Wiley & Sons, Inc.
利用代谢信号探索代谢表型的遗传景观
MetaboSignal是一个R/Bioconductor软件包，旨在探索基因和代谢物之间的关系，使用京都基因与基因组百科全书(KEGG)作为其主要数据库。它是一种基于网络的方法，允许覆盖代谢和信号通路，并探索基因(信号或代谢基因)和代谢物之间的拓扑关系。代谢信号非常适合在代谢组全基因组关联研究(mGWAS)中识别候选基因，特别是在反式作用关联的情况下。它还可以用于提供遗传模型中观察到的代谢紊乱模式的机制解释，以及识别信号基因的新靶代谢途径。©2018 by John Wiley &儿子,Inc。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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