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{"title":"A Brief Guide to Studying Fear in Developing Rodents: Important Considerations and Common Pitfalls","authors":"Caitlin S.M. Cowan, Rick Richardson","doi":"10.1002/cpns.44","DOIUrl":null,"url":null,"abstract":"<p>Development is a time of rapid change that sets the pathway to adult functioning across all aspects of physical and mental health. Developmental studies can therefore offer insight into the unique needs of individuals at different stages of normal development as well as the etiology of various disease states. The aim of this overview is to provide an introduction to the practical implementation of developmental studies in rats and mice, with an emphasis on the study of learned fear. We first discuss how developmental factors may influence experimental outcomes for any study. This is followed by a discussion of methodological issues to consider when conducting studies of developing rodents, highlighting examples from the literature on learned fear. Throughout, we offer some recommendations to guide researchers on best practice in developmental studies. © 2018 by John Wiley & Sons, Inc.</p>","PeriodicalId":40016,"journal":{"name":"Current Protocols in Neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cpns.44","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Protocols in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cpns.44","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Neuroscience","Score":null,"Total":0}
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Abstract
Development is a time of rapid change that sets the pathway to adult functioning across all aspects of physical and mental health. Developmental studies can therefore offer insight into the unique needs of individuals at different stages of normal development as well as the etiology of various disease states. The aim of this overview is to provide an introduction to the practical implementation of developmental studies in rats and mice, with an emphasis on the study of learned fear. We first discuss how developmental factors may influence experimental outcomes for any study. This is followed by a discussion of methodological issues to consider when conducting studies of developing rodents, highlighting examples from the literature on learned fear. Throughout, we offer some recommendations to guide researchers on best practice in developmental studies. © 2018 by John Wiley & Sons, Inc.
研究发育中的啮齿动物的恐惧的简要指南:重要的考虑和常见的陷阱
发展期是一个快速变化的时期,它为身心健康各方面的成人功能开辟了道路。因此,发育研究可以深入了解正常发育不同阶段个体的独特需求以及各种疾病状态的病因。这篇综述的目的是介绍在大鼠和小鼠中进行发育研究的实际实施,重点是对习得性恐惧的研究。我们首先讨论发育因素如何影响任何研究的实验结果。随后讨论了在进行发育中的啮齿动物研究时要考虑的方法问题,突出了关于习得性恐惧的文献中的例子。在整个过程中,我们提供了一些建议,以指导研究人员在发展研究中的最佳实践。©2018 by John Wiley &儿子,Inc。
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