D M Cammisuli, A Innocenti, J Fusi, F Franzoni, C Pruneti
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引用次数: 20
Abstract
Background: Previous reviews and meta-analysis have shown that physical activity has positive effects on cognition in healthy elderly as well as in patients with Mild Cognitive Impairment, even if with a minor effect whereas less is known about the effectiveness of aerobic exercise in patients with Alzheimer's Disease (AD).
Objectives: The aim of the present study was to systematically review the evidence from randomized controlled trials (RCTs) designed to evaluate aerobic exercise effects upon cognition in AD patients.
Methods: PubMed, Cochrane, Web of Science and DARE databases were analytically searched for RCTs including aerobic exercise interventions for AD patients.
Results: There is scarce evidence that aerobic exercise improves cognition in AD patients. Overall, the included studies reported only positive effects for patients'global cognition after intervention, mainly due to a lack of accurate neuropsychological assessment of each cognitive domain. Whether the bene ts of exercise are evident in all stages of AD pathology remain also uncertain.
Conclusions: Standardized protocols, larger and more rigorous RCTs with long-term follow-ups may provide better insight into the effects of aerobic exercise on cognitive deterioration characterizing people with AD.
背景:先前的综述和荟萃分析表明，体育活动对健康老年人和轻度认知障碍患者的认知有积极影响，即使影响很小，而有氧运动对阿尔茨海默病(AD)患者的有效性知之甚少。目的:本研究的目的是系统地回顾随机对照试验(RCTs)的证据，这些试验旨在评估有氧运动对AD患者认知能力的影响。方法:分析检索PubMed、Cochrane、Web of Science和DARE数据库中包含有氧运动干预AD患者的随机对照试验。结果:有氧运动能改善AD患者认知能力的证据较少。总的来说，纳入的研究仅报告了干预后对患者整体认知的积极影响，主要是由于缺乏对每个认知领域的准确神经心理学评估。运动的益处是否在阿尔茨海默病病理的所有阶段都很明显仍不确定。结论:标准化的方案，更大规模和更严格的随机对照试验，长期随访，可以更好地了解有氧运动对AD患者认知功能减退的影响。
期刊介绍：
Archives Italiennes de Biologie - a Journal of Neuroscience- was founded in 1882 and represents one of the oldest neuroscience journals in the world. Archives publishes original contributions in all the fields of neuroscience, including neurophysiology, experimental neuroanatomy and electron microscopy, neurobiology, neurochemistry, molecular biology, genetics, functional brain imaging and behavioral science.
Archives Italiennes de Biologie also publishes monographic special issues that collect papers on a specific topic of interest in neuroscience as well as the proceedings of important scientific events.
Archives Italiennes de Biologie is published in 4 issues per year and is indexed in the major collections of biomedical journals, including Medline, PubMed, Current Contents, Excerpta Medica.
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