Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index.

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-07-30 eCollection Date: 2018-01-01 DOI:10.1177/1179552218791173

Toshimi Chiba, Kazuyuki Suzuki, Takayuki Matsumoto

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引用次数: 9

Abstract

We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn's disease (CD) activity index (CDAI) in patients with CD.

Methods: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity.

Results: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA.

Conclusions: In patients with CD, plasma amino acids appear to be associated with disease activity.

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克罗恩病血浆无氨基酸谱:与克罗恩病活动指数的关系

我们旨在阐明血浆游离氨基酸(PFAA)谱与克罗恩病(CD)活性指数(CDAI)之间的关系。方法:我们测量了29例CD患者的空腹PFAA浓度及其与疾病活性的相关性。结果:在所有患者中，CDAI与缬氨酸、蛋氨酸、亮氨酸、组氨酸、色氨酸、丙氨酸、酪氨酸、总氨基酸(TAAs)、非必需氨基酸(NEAAs)、必需氨基酸(EAAs)和支链氨基酸(BCAAs)浓度之间存在显著相关性。在回肠-结肠型CD患者中，CDAI与缬氨酸、组氨酸、色氨酸、谷氨酰胺、TAA、NEAA、EAA和BCAA之间存在显著相关性。在回肠型中，CDAI与苏氨酸、缬氨酸、组氨酸、丝氨酸和甘氨酸之间存在显著相关性。在结肠型中，CDAI与缬氨酸、组氨酸、色氨酸、TAA、NEAA、EAA和BCAA之间存在显著相关性。结论:在CD患者中，血浆氨基酸似乎与疾病活动性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Medicine Insights. Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

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8 weeks