The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-07-23 DOI:10.1007/s40778-018-0139-3

Daniel E Morales-Mantilla, Katherine Y King

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引用次数: 59

Abstract

Purpose of review: Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that participates in the regulation of hematopoietic stem cells (HSC) during development and under homeostatic conditions. IFN-γ also plays a key pathogenic role in several diseases that affect hematopoiesis including aplastic anemia, hemophagocytic lymphohistiocytosis, and cirrhosis of the liver.

Recent findings: Studies have shown that increased IFN-γ negatively affects HSC homeostasis, skewing HSC towards differentiation over self-renewal and eventually causing exhaustion of the HSC compartment.

Summary: Here, we explore the mechanisms by which IFN-γ regulates HSC in both normal and pathological conditions. We focus on the role of IFN-γ signaling in HSC fate decisions, and the transcriptional changes it elicits. Elucidating the mechanisms through which IFN-γ regulates HSCs may lead to new therapeutic options to prevent or treat adverse hematologic effects of the many diseases to which IFN-γ contributes.

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干扰素γ在造血干细胞发育、体内平衡和疾病中的作用。

综述目的:干扰素-γ (IFN-γ)是一种促炎细胞因子，参与造血干细胞(HSC)在发育和稳态条件下的调节。IFN-γ在影响造血的几种疾病中也起着关键的致病作用，包括再生障碍性贫血、噬血细胞性淋巴组织细胞增多症和肝硬化。最近的发现:研究表明，IFN-γ的增加对HSC稳态产生负面影响，使HSC向自我更新的分化方向倾斜，最终导致HSC室衰竭。摘要:在这里，我们探讨了IFN-γ在正常和病理条件下调节HSC的机制。我们关注IFN-γ信号在HSC命运决定中的作用，以及它引发的转录变化。阐明IFN-γ调节造血干细胞的机制可能会带来新的治疗选择，以预防或治疗IFN-γ导致的许多疾病的不良血液学效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

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期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.