[Selective autophagy mechanism against Group A Streptococcus infection].

Takashi Nozawa
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引用次数: 4

Abstract

Autophagy acts as an intracellular host defense system against invading pathogenic microorganisms such as Group A Streptococcus (GAS). Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase Rab proteins. Here, we revealed Rab GTPase network that regulate autophagosome formation against GAS. A unique set of Rab GTPases coordinates autophagy to enable to form huge autophagosomes surrounding GAS by linking recycling endosomes and trans Golgi-network. We also found that NLRP4, one of intracellular pathogen recognition receptor, directs Rho signaling to facilitate autophagosome formation. In this article, we would like to show our findings on how host autophagy regulators coordinate autophagy during GAS infection.

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[抗A群链球菌感染的选择性自噬机制]。
自噬作为细胞内宿主防御入侵病原微生物如A群链球菌(GAS)的防御系统。自噬是一种膜介导的降解系统,受细胞膜内运输调节剂的调节,包括小的GTPase Rab蛋白。在这里,我们发现了调控自噬体形成的rabgtpase网络。一组独特的Rab GTPases通过连接循环内体和反式高尔基网络来协调自噬,从而在GAS周围形成巨大的自噬体。我们还发现NLRP4是细胞内病原体识别受体之一,它指导Rho信号传导促进自噬体的形成。在这篇文章中,我们想展示我们关于宿主自噬调节因子如何在GAS感染期间协调自噬的发现。
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[Study on biofilm formation and heterogeneity in Clostridium perfringens]. [Wakate Colosseum for Bacteriology]. [Award Lecture]. [Workshop]. [Luncheon Seminar].
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