Precision medicine in pediatric oncology.

IF 2.4 Q1 PEDIATRICS Molecular and cellular pediatrics Pub Date : 2018-08-31 DOI:10.1186/s40348-018-0084-3
Stefan E G Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser, Klaus-Michael Debatin
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引用次数: 25

Abstract

Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and developed treatment of childhood cancer. Nevertheless, outcome in certain types of malignancies is still unfavorable. Intensification of conventional chemotherapy and radiotherapy improved outcome only marginally at the cost of acute and long-term side effects. Hence, it is necessary to develop targeted therapy strategies.Here, we review the developments and perspectives in precision medicine in pediatric oncology with a special focus on targeted drug therapies like kinase inhibitors and inducers of apoptosis, the impact of cancer genome sequencing and immunotherapy.

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儿科肿瘤学的精准医学。
自20世纪70年代以来,儿童癌症的治疗效果有了显著改善。这一成功在很大程度上是由于实施了标准化和发展儿童癌症治疗的合作临床研究试验组。然而,某些类型的恶性肿瘤的结果仍然是不利的。以急性和长期副作用为代价,常规化疗和放疗的强化只能略微改善预后。因此,有必要制定针对性的治疗策略。在此,我们回顾了儿科肿瘤精准医学的发展和前景,特别关注激酶抑制剂和细胞凋亡诱导剂等靶向药物治疗,癌症基因组测序和免疫治疗的影响。
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