Precision medicine in pediatric oncology.

IF 2.4 Q1 PEDIATRICS Molecular and cellular pediatrics Pub Date : 2018-08-31 DOI:10.1186/s40348-018-0084-3
Stefan E G Burdach, Mike-Andrew Westhoff, Maximilian Felix Steinhauser, Klaus-Michael Debatin
{"title":"Precision medicine in pediatric oncology.","authors":"Stefan E G Burdach,&nbsp;Mike-Andrew Westhoff,&nbsp;Maximilian Felix Steinhauser,&nbsp;Klaus-Michael Debatin","doi":"10.1186/s40348-018-0084-3","DOIUrl":null,"url":null,"abstract":"<p><p>Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and developed treatment of childhood cancer. Nevertheless, outcome in certain types of malignancies is still unfavorable. Intensification of conventional chemotherapy and radiotherapy improved outcome only marginally at the cost of acute and long-term side effects. Hence, it is necessary to develop targeted therapy strategies.Here, we review the developments and perspectives in precision medicine in pediatric oncology with a special focus on targeted drug therapies like kinase inhibitors and inducers of apoptosis, the impact of cancer genome sequencing and immunotherapy.</p>","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40348-018-0084-3","citationCount":"25","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and cellular pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40348-018-0084-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 25

Abstract

Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and developed treatment of childhood cancer. Nevertheless, outcome in certain types of malignancies is still unfavorable. Intensification of conventional chemotherapy and radiotherapy improved outcome only marginally at the cost of acute and long-term side effects. Hence, it is necessary to develop targeted therapy strategies.Here, we review the developments and perspectives in precision medicine in pediatric oncology with a special focus on targeted drug therapies like kinase inhibitors and inducers of apoptosis, the impact of cancer genome sequencing and immunotherapy.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
儿科肿瘤学的精准医学。
自20世纪70年代以来,儿童癌症的治疗效果有了显著改善。这一成功在很大程度上是由于实施了标准化和发展儿童癌症治疗的合作临床研究试验组。然而,某些类型的恶性肿瘤的结果仍然是不利的。以急性和长期副作用为代价,常规化疗和放疗的强化只能略微改善预后。因此,有必要制定针对性的治疗策略。在此,我们回顾了儿科肿瘤精准医学的发展和前景,特别关注激酶抑制剂和细胞凋亡诱导剂等靶向药物治疗,癌症基因组测序和免疫治疗的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.20
自引率
0.00%
发文量
0
期刊最新文献
Early metabolic and hemodynamic indicators of kidney dysfunction in mice offspring from parental low protein diet. Fatty acids from nutrition sources for preterm infants and their effect on plasma fatty acid profiles. Description of bone health in adolescents and young persons with Klinefelter syndrome – results from a pilot study Monogenic lupus – from gene to targeted therapy B cell academy of the gut: an update on gut associated germinal centre B cell dynamics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1