Reliable calibration by nonlinear standard addition method in the presence of additive interference effects.

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2018-08-07 DOI:10.1007/s00706-018-2203-1

Marcin Wieczorek, Marek Dębosz, Paweł Świt, Aleksandra Piech, Joanna Kasperek, Paweł Kościelniak

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引用次数: 8

Abstract

Abstract: The possibility of adapting the Standard Addition Method (SAM) to calibration in very difficult analytical conditions, namely when there is a need to determine an analyte with the use of nonlinear calibration graph and in the presence of matrix components causing additive interference effect, is investigated. To this aim the SAM in the common version and the Chemical H-point Standard Addition Method (C-HPSAM) realized by the flow injection technique were applied. Specifically, a flow manifold was used for construction of a set of nonlinear calibration graphs in different chemical conditions. As the graphs were intersected indicating both the additive interference effect and the analytical result free of this effect, the analyte concentration in the sample was able to be obtained with improved accuracy. The applicability of this approach was verified on the example of spectrophotometric determination of paracetamol in pharmaceuticals and of total acidity in wines. The C-HPSAM method enabled complete compensation of the additive effect and obtaining analytical results at a relative error not exceeding 6.0%.

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在存在加性干扰效应的情况下，采用非线性标准加法法进行可靠标定。

摘要:研究了标准添加法(SAM)在非常困难的分析条件下，即需要使用非线性校准图确定分析物和存在引起加性干扰效应的矩阵成分时，适用于校准的可能性。为此，采用了通用版的化学h点标准添加法和流动注射技术实现的化学h点标准添加法(C-HPSAM)。具体而言，利用流动流形构造了不同化学条件下的一组非线性标定图。由于图形相交，表明加性干扰效应和分析结果没有这种影响，因此能够以更高的精度获得样品中的分析物浓度。以分光光度法测定药品中的扑热息痛和葡萄酒中的总酸度为例，验证了该方法的适用性。C-HPSAM方法完全补偿了加性效应，得到的分析结果相对误差不超过6.0%。图形化的简介:

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来源期刊

Monatshefte Fur Chemie 化学-化学综合

CiteScore

3.70

自引率

5.60%

发文量

116

审稿时长

3.3 months

期刊介绍： "Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.