Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Pediatric neurology Pub Date : 2018-09-01 DOI:10.1016/j.pediatrneurol.2018.07.016

Rachel L. Randell MD , Ashley V. Adams BA , Heather Van Mater MD

引用次数: 37

Abstract

Background

Autoimmune encephalitis can result in significant neurological and psychiatric morbidity and mortality in patients of all ages and often does not respond to standard therapies. Recent reports suggest efficacy of tocilizumab, a monoclonal antibody against interleukin 6, in refractory autoimmune encephalitis.

Results

We describe three children with refractory autoimmune encephalitis who experienced a robust, immediate clinical response following treatment with tocilizumab.

Conclusion

These findings support the efficacy and short-term safety of tocilizumab as a third-line treatment for refractory autoimmune encephalitis in children.

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托珠单抗治疗难治性自身免疫性脑炎:一系列儿科病例

背景:自身免疫性脑炎可在所有年龄的患者中导致显著的神经和精神发病率和死亡率，并且通常对标准治疗无效。最近的报道表明tocilizumab，一种针对白细胞介素6的单克隆抗体，对难治性自身免疫性脑炎有效。结果:我们描述了3例难治性自身免疫性脑炎患儿，他们在接受托珠单抗治疗后立即出现了强劲的临床反应。结论:这些研究结果支持tocilizumab作为儿童难治性自身免疫性脑炎三线治疗的有效性和短期安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.