A surgical perspective report on melanoma management.

IF 0.7 Q4 ONCOLOGY Melanoma Management Pub Date : 2017-05-01 Epub Date: 2017-05-15 DOI:10.2217/mmt-2016-0031

Brian D Wernick, Neha Goel, Francis Sw Zih, Jeffrey M Farma

引用次数: 6

Abstract

Management of melanoma includes wide excision with adequate margins and lymph node biopsy depending on the depth of the lesion, with subsequent completion lymphadenectomy for positive sentinel node. Locally advanced disease can be approached in several different ways depending on a variety of patient and disease-specific factors. These include surgical resection, isolated limb perfusion and infusion and intralesional injection therapy such as talimogene laherparepvec, IL-2 and Bacille Calmette-Guerin. Ongoing controversy exists regarding the utility of completion lymphadenectomy, and trials such as MSLT-2 will attempt to shed light on this issue. The future of melanoma management will likely focus on expanding the use of immunotherapy, allowing for narrower surgical margins, particularly in sensitive anatomic areas, and limiting the number of completion lymphadenectomies.

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黑色素瘤治疗的外科视角报告。

黑色素瘤的治疗包括广泛切除足够的边缘和淋巴结活检，这取决于病变的深度，随后对阳性前哨淋巴结进行完整的淋巴结切除术。局部晚期疾病可以根据各种患者和疾病特定因素采用几种不同的方法进行治疗。这些治疗包括手术切除、孤立肢体灌注输注和病灶内注射治疗，如talimogene laherparepvec、IL-2和Bacille Calmette-Guerin。关于完全淋巴结切除术的效用存在持续的争议，MSLT-2等试验将试图阐明这一问题。黑色素瘤治疗的未来可能会集中在扩大免疫疗法的使用，允许更窄的手术范围，特别是在敏感的解剖区域，并限制完全淋巴结切除术的数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.