D S Laptev, S G Petunov, D V Bobkov, A S Radilov, V R Rembovskiy
{"title":"[INFLUENCE OF Р-ENDORPHIN ON FUNCTIONAL ACTIVITY OF ISOLATED RAT HEART].","authors":"D S Laptev, S G Petunov, D V Bobkov, A S Radilov, V R Rembovskiy","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We have studied the effect of Р-endorphin (an endogenous opioid peptide) on the functional characteristics of isolated rat heart. In physiological concentrations (6.3 X 10-10 M) Р-endorphin induces a negative inotropic effect, accompanied by a slight decrease in the heart rate, and has no effect on the perfusion pressure of the coronary vessels. It is shown that the effect of Р-endorphin is mediated by 5-opioid receptors. ATP-dependent K+-channels contribute the greatest contribution to the implementation of the effect of Р-endorphin on the isolated heart of a rat. The role of voltage-dependent K+-channels and NO-mediated mechanisms in the implementation of the effects of Р-endorphin is minor.</p>","PeriodicalId":21358,"journal":{"name":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"102 11","pages":"1343-51"},"PeriodicalIF":0.0000,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We have studied the effect of Р-endorphin (an endogenous opioid peptide) on the functional characteristics of isolated rat heart. In physiological concentrations (6.3 X 10-10 M) Р-endorphin induces a negative inotropic effect, accompanied by a slight decrease in the heart rate, and has no effect on the perfusion pressure of the coronary vessels. It is shown that the effect of Р-endorphin is mediated by 5-opioid receptors. ATP-dependent K+-channels contribute the greatest contribution to the implementation of the effect of Р-endorphin on the isolated heart of a rat. The role of voltage-dependent K+-channels and NO-mediated mechanisms in the implementation of the effects of Р-endorphin is minor.
我们研究了Р-endorphin(一种内源性阿片肽)对离体大鼠心脏功能特性的影响。在生理浓度(6.3 X 10-10 M) Р-endorphin诱导负性肌力作用，伴有心率轻微下降，对冠状血管灌注压力没有影响。结果表明Р-endorphin的作用是由5-阿片受体介导的。atp依赖的K+通道对Р-endorphin对大鼠离体心脏的作用的实现贡献最大。电压依赖的K+通道和no介导的机制在Р-endorphin效应的实现中的作用是次要的。
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
