[INTERACTION EPITHELIUM AND SMOOTH MUSCLE IN THE WALLS OF THE AIRWAYS IN THE NORMAL CONDITIONS AND WHEN FORMING OF HYPERREACTIVITY].

Abstract

In the present study was to investigate the effect epithelium on the tone smooth muscle of the airways of guinea pigs under physiological conditions and when forming of experimental asthma. It was found that the amplitude of contractile responses decreased by histaminergic, and serotonergic effects in the presence of epithelium in the control group. Influence epithelium dilatation adrenergic reactions depended on the type of pretreatment factors. The amplitude of the relaxation was reduced in the case of pre-treatment with a solution of potassium, the amount of dilation increased by pretreatment with histamine. The impact of epithelium on contractile responses of smooth muscles disappeared when forming of hyperreactivity.