[EFFECTS OF ORALLY AND PARENTERALLY ADMINISTERED ANALOGS OF PEPTIDE HORMONES ON RENAL WATER AND ION TRANSPORT].

Abstract

In experiments with female Wistar rats it was shown that analogs of neurohypophysial hormones administered to gastrointestinal tract preserved their specific physiological activity - they increased solute-free water reabsorption and urinary sodium and potassium excretion. Doses of deamino-vasotocin exerted antidiuretic and natriuretic effects following its oral administration were 50 and 200 times higher compared to maximal effective ones after intramuscular injection. Inhibition of gastrointestinal proteases by aprotinine enhanced effects of nonapeptides; the amount of peptide absorbed from the intestine under these conditions was approximately 0.5 % of orally introduced substance. In contrast to analogs of neurohypophysial nonapeptides, glucagon-like peptide-1 mimetic (exenatide) did not exert its physiological effects after oral administration, whereas it increased urinary sodium and potassium excretion following intramuscular injection.