Strategies for screening cord blood for a public cord blood bank in high HIV prevalence regions.

IF 1.1 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Global Health Epidemiology and Genomics Pub Date : 2018-05-15 eCollection Date: 2018-01-01 DOI:10.1017/gheg.2018.6
M Meissner-Roloff, L Gaggia, M Vermeulen, A F H Mazanderani, N M du Plessis, H C Steel, M S Pepper
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引用次数: 8

Abstract

The probability of a Black African finding a matched unrelated donor for a hematopoietic stem cell transplant is minimal due to the high degree of genetic diversity amongst individuals of African origin. This problem could be resolved in part by the establishment of a public cord blood (CB) stem cell bank. The high prevalence of human immunodeficiency virus (HIV) amongst women attending antenatal clinics in sub-Saharan Africa together with the risk of mother-to-child transmission increases the risk of transplant transmissible infection. In addition to screening the mother in a period inclusive of 7 days prior to the following delivery, we propose that all CB units considered for storage undergo rigorous and reliable screening for HIV. The Ultrio-plus® assay is a highly specific and sensitive test for detecting HIV, hepatitis-B and hepatitis-C viruses in peripheral blood. We validated the Ultrio-plus® assay for analytical sensitivity in detecting HIV in CB at the level of detection of the assay. Until more comprehensive and sensitive methods are developed, the sensitivity and reliability of the Ultrio-plus® assay suggest that it could be used for the routine screening of CB units in conjunction with currently recommended maternal screening to reduce the risk of transplant transmissible infection.

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艾滋病毒高流行区公共脐带血库脐带血筛查战略。
非洲黑人找到匹配的非亲属供体进行造血干细胞移植的可能性很小,因为非洲裔个体之间存在高度的遗传多样性。建立公共脐带血(CB)干细胞库可以部分解决这个问题。在撒哈拉以南非洲,在产前诊所就诊的妇女中,人体免疫缺陷病毒(艾滋病毒)的高流行率以及母婴传播的风险增加了移植传播感染的风险。除了在分娩前7天对母亲进行筛查外,我们建议所有考虑储存的CB单位都要进行严格可靠的艾滋病毒筛查。Ultrio-plus®检测是一种高度特异性和敏感性的检测外周血中HIV、乙型肝炎和丙型肝炎病毒的检测方法。我们在检测水平上验证了Ultrio-plus®检测CB中HIV的分析灵敏度。在开发出更全面、更灵敏的方法之前,Ultrio-plus®检测方法的敏感性和可靠性表明,它可以与目前推荐的孕产妇筛查一起用于常规筛查CB单位,以降低移植传播感染的风险。
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来源期刊
Global Health Epidemiology and Genomics
Global Health Epidemiology and Genomics PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.40
自引率
0.00%
发文量
10
审稿时长
20 weeks
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