[Reproductive Toxicological Research as Countermeasures to Declining Birth Rate].

Abstract

Research into reproductive toxicology may lead to one of the countermeasures to the declining birth rate observed in industrialized countries. Some chemicals can pose risks to human reproduction that is a multistage process starting from the development of male and female germ cells to childbirth and the subsequent growth and development of the child. In Japan, the government has amended law enforcement, i.e., the Regulations on Labor Standards for Women, recently to improve protection for pregnant women against reproductive chemical hazards in workplaces. Male workers may also be protected against such hazards if appropriate risk assessment and the following management are performed as required by the Industrial Safety and Health Law. However, it remains a concern that an unexpected adverse outcome due to an unknown reproduction hazard may occur owing to the use of chemicals not listed in the regulations. This is because the toxicity of a large number of chemicals has not been entirely revealed. Moreover, it is often difficult to determine from a Safety Data Sheet for a product of interest whether the chemicals contained in the product do not have reproductive toxicity or the toxicity data are just not available because of lack of pertinent studies. Thus, researchers in the field of occupational and environmental health need to make effort to fill in such data gaps and to raise the awareness among the public the importance of experimental and epidemiological studies. Study designs for investigating subclinical effects, mechanisms of reproductive toxicity, exposure levels, and dose-response relationships to determine environmental standards are also required.