[THE IMPACT OF XENOTRANSPLANTATION OF NEUROGENIC STEM CELLS IN COMPLEX WITH THE TISSUE MATRIX NEUROGELTM ON THE POSTTRAUMATIC SPASTICITY SYNDROME COURSE IN EXPERIMENT].

Abstract

The impact of implantation of synthetic matrix NeuroGelTM together with neurogenic stem cells (NSC) on the course of posttraumatic spasticity syndrome was studied. Тhe laboratory animals were white mongrel male rats (5 mo, 250 g); the trauma simulation – transsection of the left half of spinal cord (SC) on the ТХІ level. Experimental group 1 consisted of a SC trauma, homotopic implantation of NeuroGelTM together with NSC of fetal (Е17) mice hippocampus (n=20); while group 2 – a SC trauma, homotopic implantation of NeuroGelTM (n=20); and group 3 – a SC trauma (n=16). Investigation of the function index and the spasticity index of posterior ipsilateral extremity was done in accordance to Basso-Beattie-Bresnahan and Ashworth scales. Association of the function index and the spasticity index of posterior ipsilateral extremity in all groups in various variants of the samples formation is ambiguous, witnessing possibility of additional correlation between these characteristics of a movement system. The NSC xenotransplantation in conjunction with NeuroGelTM changes the spasticity syndrome course, creates conditions for its facilitation in remote period after a SC trauma.