Angelica Boeve, Tanis J Ferman, Jeremiah Aakre, Erik St Louis, Michael Silber, Mary Machulda, Julie Fields, Neill Graff-Radford, Michelle Mielke, Yonas Geda, David Jones, Jonathon Graff-Radford, David Knopman, Ronald Petersen, Brad Boeve
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引用次数: 11
Abstract
There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P < .05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P < .01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.
没有比较阿尔茨海默病痴呆(AD)、路易体痴呆(DLB)和行为变异性额颞叶痴呆(bvFTD)患者的过度日间嗜睡(EDS)。我们确定了符合这些障碍标准的轻度痴呆患者，并完成了Epworth嗜睡量表(ESS)。样本包括17例bvFTD, 111例AD和31例DLB。ESS评分≥10分为异常，与EDS一致。以年龄和性别为协变量的分析显示，与其他组相比，DLB的平均ESS评分更高(DLB 13.9 [5]， bvFTD 9.6 [8]， AD 8.8 [5]， P < 0.05)。与bvFTD或AD相比，DLB患者ESS评分≥10的可能性更大(DLB 81% vs bvFTD 47% vs AD 45%， P < 0.01)。在轻度痴呆患者中，DLB患者EDS最高，bvFTD和AD患者EDS相对较低。
期刊介绍：
American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).
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