HPV16 viral characteristics in primary, recurrent and metastatic vulvar carcinoma

IF 3.2 Papillomavirus Research Pub Date : 2018-12-01 DOI:10.1016/j.pvr.2018.10.008

Gabriella Lillsunde Larsson , Malin Kaliff , Bengt Sorbe , Gisela Helenius , Mats G. Karlsson

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引用次数: 3

Abstract

Vulvar carcinoma is the fourth most common gynecological malignancy. Two separate carcinogenic pathways are suggested, where one is associated with the human papillomavirus (HPV) and HPV16 the most common genotype.

The aim of this study was to evaluate HPV-markers in a set of primary tumors, metastases and recurrent lesions of vulvar squamous cell carcinomas (VSCC). Ten HPV16-positive VSCC with metastatic regional lymph nodes, distant lymphoid/hematogenous metastases or local recurrent lesions were investigated for HPV genotype, HPV16 variant, HPV16 viral load, HPV16 integration and HPV16 E2BS3 and 4 methylation.

In all 10 analyzed case series, the same HPV genotype (HPV16), HPV16 variant and level of viral load were detected in all lesions within a patient case. Primary tumors with a high E2/E6 ratio were found to have fewer vulvar recurrences and/or metastases after diagnosis and treatment. Also, a significantly lower viral load was evident in regional lymph nodes compared to primary tumors.

The data presented strengthens the evidence for a clonal HPV-induced pathway for vulvar carcinoma

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HPV16病毒在原发性、复发性和转移性外阴癌中的特征

外阴癌是第四常见的妇科恶性肿瘤。提出了两种不同的致癌途径，其中一种与人类乳头瘤病毒(HPV)和最常见的基因型HPV16有关。本研究的目的是评估hpv标志物在外阴鳞状细胞癌(VSCC)的原发肿瘤、转移和复发病变中的作用。我们对10例HPV16阳性的VSCC进行了HPV基因型、HPV16变异、HPV16病毒载量、HPV16整合、HPV16 E2BS3和4甲基化的检测。在所有10例分析病例系列中，在患者病例的所有病变中检测到相同的HPV基因型(HPV16)、HPV16变体和病毒载量水平。E2/E6比值高的原发肿瘤在诊断和治疗后外阴复发和/或转移较少。此外，与原发肿瘤相比，区域淋巴结的病毒载量明显较低。所提出的数据加强了hpv克隆诱导外阴癌途径的证据

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来源期刊

Papillomavirus Research VIROLOGY-

自引率

0.00%

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审稿时长

14 weeks

期刊介绍： The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.