The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis.

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2018-10-21 DOI:10.1155/2018/2586916
Olga Reitblat, Tsahi T Lerman, Ornit Cohen, Tatiana Reitblat
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引用次数: 3

Abstract

Objectives: To assess the correlation between prednisone and methotrexate (MTX) treatment duration and dosage with the TST induration diameter of the TST reaction among rheumatoid arthritis (RA) patients.

Method: We retrospectively analyzed consecutive cases of RA patients who were TNF-i therapy candidates. TST measurements, prednisone and methotrexate dosages, and treatment durations were recorded. A control group was randomly selected from healthy subjects. We compared TST reaction size between the following three groups: RA patients with current prednisone treatment, RA prednisone naïve patients, and healthy individuals.

Results: Our study sample comprised 43 RA patients with prednisone treatment, 22 prednisone naïve patients, and 195 healthy subjects. There was no significant difference in mean TST between the groups (5.3±6.6, 7.8±6.2, and 7.6±7.0, respectively, p=0.149). No correlation was noted between TST size and prednisone u-y (r=0.229, p=0.140) or methotrexate u-y in patients with and without prednisone therapy (r=0.219, p=0.158; and r=-0.293, p=0.186, respectively).

Conclusions: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated.

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泼尼松对类风湿性关节炎患者结核菌素皮试反应的影响。
目的:评估泼尼松和甲氨蝶呤(MTX)治疗时间和剂量与类风湿性关节炎(RA)患者TST反应的TST硬化直径的相关性。方法:我们回顾性分析了TNF-i治疗候选RA患者的连续病例。记录TST测量、泼尼松和甲氨蝶呤剂量以及治疗持续时间。对照组是从健康受试者中随机选择的。我们比较了以下三组患者的TST反应大小:目前接受泼尼松治疗的RA患者、未接受泼尼松松治疗的患者和健康人。结果:我们的研究样本包括43名接受泼尼松治疗的RA患者、22名泼尼松幼稚患者和195名健康受试者。两组之间的平均TST没有显著差异(分别为5.3±6.6、7.8±6.2和7.6±7.0,p=0.149)。在接受和不接受泼尼松治疗的患者中,TST大小与泼尼松u-y(r=0.229,p=0.140)或甲氨蝶呤u-y之间没有相关性(分别为r=0.219,p=0.158;r=-0.293,p=0.186)患者可能不会受到泼尼松治疗的影响。此外,RA患者的TST反应可能与健康人相似。因此,我们建议应该重新评估TST反应为5mm的标准来定义我们人群中的潜在结核病感染。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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