Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis.

IF 1.9 3区医学 Q1 Dentistry Korean Journal of Orthodontics Pub Date : 2018-11-01 Epub Date: 2018-09-14 DOI:10.4041/kjod.2018.48.6.395

Shifat A Nowrin, Saidi Jaafar, Norma Ab Rahman, Rehana Basri, Mohammad Khursheed Alam, Fazal Shahid

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引用次数: 15

Abstract

Objective: To date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR.

Methods: A complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017.

Results: On the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment.

Conclusions: More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

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遗传多态性与外根尖吸收的关系:一项系统综述和荟萃分析。

目的:迄今为止，仅有少数研究探讨了遗传多态性与外根尖吸收(EARR)之间的关系。因此，本系统综述的目的是探讨不同基因多态性与EARR之间的关系。方法:由两名独立审稿人进行完整的文献检索。检索了PubMed、Science Direct和Scopus数据库。此外，手工检索了所有教科书和相关文章的参考书目。使用2017年2月28日之前输入电子数据库的数据进行meta分析。结果:在检索的基础上，我们分别确定了17篇和7篇出版物用于系统评价和荟萃分析。采用比值比(OR)评价白细胞介素1B(+3954)多态性与EARR风险的关系。研究的总体OR被用来估计EARR的风险。然而，在接受正畸治疗的患者中，没有发现EARR风险的关联，也没有明显的发表偏倚。结论:有必要进一步研究基因多态性与EARR之间的关系，以更好地确定可能的相互作用的特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Orthodontics Dentistry-Orthodontics

CiteScore

2.60

自引率

10.50%

发文量

审稿时长

3 months

期刊介绍： The Korean Journal of Orthodontics (KJO) is an international, open access, peer reviewed journal published in January, March, May, July, September, and November each year. It was first launched in 1970 and, as the official scientific publication of Korean Association of Orthodontists, KJO aims to publish high quality clinical and scientific original research papers in all areas related to orthodontics and dentofacial orthopedics. Specifically, its interest focuses on evidence-based investigations of contemporary diagnostic procedures and treatment techniques, expanding to significant clinical reports of diverse treatment approaches. The scope of KJO covers all areas of orthodontics and dentofacial orthopedics including successful diagnostic procedures and treatment planning, growth and development of the face and its clinical implications, appliance designs, biomechanics, TMJ disorders and adult treatment. Specifically, its latest interest focuses on skeletal anchorage devices, orthodontic appliance and biomaterials, 3 dimensional imaging techniques utilized for dentofacial diagnosis and treatment planning, and orthognathic surgery to correct skeletal disharmony in association of orthodontic treatment.