Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention.

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2018-01-01 Epub Date: 2018-11-23 DOI:10.1159/000494331
Dana E Lowry, Peri H Fenwick, Kaitlin Roke, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Paula Brauer, Dawna Royall, Angelo Tremblay, Doug Klein, David M Mutch
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引用次数: 8

Abstract

Background: Metabolic syndrome (MetS) comprises a cluster of risk factors including central obesity, hypertension, dyslipidemia, and impaired glucose homeostasis. Lifestyle interventions that promote improvements in diet quality and physical activity represent a first line of therapy for MetS. However, varying responses to lifestyle interventions are well documented and may be partially explained by underlying genetic differences. The aim of this study was to investigate if variants in genes previously associated with MetS influence the magnitude of change in MetS risk during a 1-year lifestyle intervention.

Methods: The present study used data collected from the Canadian Health Advanced by Nutrition and Graded Exercise study cohort (n = 159 men and women) to investigate the effect of 17 candidate single nucleotide polymorphisms (SNPs) on response to a 1-year lifestyle intervention. Associations between SNPs and the continuous MetS (cMetS) score, as well as individual MetS components, were examined.

Results: Reductions in cMetS score at both 3 months and 1 year were significantly associated with 2 variants: rs662799 (A/G) in apolipoprotein A5 (APOA5) and rs1501299 (G/T) in adiponectin (ADIPOQ). Individuals carrying a minor T allele in rs1501299 experienced a greater reduction in cMetS score at both 3 months and 1 year, whereas major allele AA homozygotes in rs662799 experienced greater reductions in cMetS score during the intervention. No associations were identified between the aforementioned SNPs and individual components of MetS. Both un-weighted and weighted genetic risk scores (GRS) using these 2 SNPs revealed that individuals carrying none of the risk alleles experienced significantly greater reductions in cMetS score after 1 year.

Conclusions: The findings from the current study suggest that individuals with certain genotypes may benefit more from a lifestyle intervention for MetS and that specific variants, either independently or as part of a GRS, could be used as a nutrigenomic tool to tailor the intervention to reduce the risk of MetS.

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在为期一年的生活方式干预中,APOA5和ADIPOQ变异对代谢综合征有中度改善。
背景:代谢综合征(MetS)由一系列危险因素组成,包括中枢性肥胖、高血压、血脂异常和葡萄糖稳态受损。促进改善饮食质量和身体活动的生活方式干预是治疗MetS的一线方法。然而,对生活方式干预的不同反应是有据可查的,可能部分解释了潜在的遗传差异。本研究的目的是调查在1年的生活方式干预期间,先前与MetS相关的基因变异是否会影响MetS风险的变化幅度。方法:本研究使用来自加拿大营养促进健康和分级运动研究队列(n = 159名男性和女性)的数据,调查17种候选单核苷酸多态性(snp)对1年生活方式干预反应的影响。研究了snp与连续MetS (cMetS)评分以及单个MetS成分之间的关系。结果:cMetS评分在3个月和1年时的降低与2个变异显著相关:载脂蛋白A5 (APOA5)的rs662799 (A/G)和脂联素(ADIPOQ)的rs1501299 (G/T)。在干预期间,携带rs1501299小T等位基因的个体在3个月和1年的cMetS评分都有较大的下降,而rs662799主要等位基因AA纯合子的cMetS评分则有较大的下降。上述snp与MetS的单个组分之间没有关联。使用这2个snp的非加权和加权遗传风险评分(GRS)显示,不携带任何风险等位基因的个体在1年后的cMetS评分显著降低。结论:目前的研究结果表明,具有特定基因型的个体可能从生活方式干预中获益更多,并且特定的变异,无论是独立的还是作为GRS的一部分,都可以作为营养基因组学工具来定制干预以降低MetS的风险。
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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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