{"title":"The Aberrant Epigenetic Modifications in the Pathogenesis of Psoriasis","authors":"Ming Zhao, Qianjin Lu","doi":"10.1016/j.jisp.2018.09.007","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 2","pages":"Pages S81-S82"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2018.09.007","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative Dermatology Symposium Proceedings","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1087002418300078","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
银屑病是一种慢性、复发性炎症性皮肤病，其特征是角化细胞异常增殖、血管增生、炎症细胞浸润到真皮和表皮。人们普遍认为银屑病的核心发病机制是T淋巴细胞功能障碍，而T淋巴细胞功能障碍受遗传和环境因素的复杂相互作用影响，包括创伤、感染、压力、药物、吸烟和饮酒(Nestle et al.， 2009)。环境诱导的表观遗传变化，包括DNA甲基化、组蛋白修饰和microrna，已被证明参与了该疾病的发病机制(Zhang et al.， 2012)。
期刊介绍：
Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.
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