Delphine Javelaud , Aurélien De Reyniès , Alain Mauviel
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Hedgehog (HH)信号在胚胎发育和成人生活中都起着重要的作用。它参与细胞分化、细胞增殖和组织极性的调节，以及干细胞的维持、组织修复和再生(Briscoe and Therond, 2013;Jiang and Hui, 2008)。三种配体，印度，索尼克和沙漠HH，可以激活这一途径。HH配体与其受体PTCH1结合(图1)解除其对SMO的抑制，导致GLI转录因子的激活和核易位(Javelaud et al.， 2012)。脊椎动物GLI基因家族由三个不同的基因GLI1、GLI2和GLI3组成，它们编码kr ppel样转录因子。GLI蛋白表现出不同的调控、生化特性和靶基因。在HH配体缺失的情况下，GLI3是该通路的主要抑制因子，而在HH配体存在的情况下，GLI2是驱动GLI1表达的主要HH效应因子(Briscoe and Therond, 2013)。
期刊介绍：
Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.
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