Immediate and short term effects of percutaneous atrial septal defect device closure on cardiac electrical remodeling in children

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Egyptian Heart Journal Pub Date : 2018-12-01 DOI:10.1016/j.ehj.2018.02.005

Alaa Mahmoud Roushdy, Hebatalla Attia, Heba Nossir

{"title":"Immediate and short term effects of percutaneous atrial septal defect device closure on cardiac electrical remodeling in children","authors":"Alaa Mahmoud Roushdy, Hebatalla Attia, Heba Nossir","doi":"10.1016/j.ehj.2018.02.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The beneficial effects of atrial septal defect (ASD) device closure on electrical cardiac remodeling are well established. The timing at which these effects starts to take place has yet to be determined.</p></div><div><h3>Objectives</h3><p>To determine the immediate and short term effects of ASD device closure on cardiac electric remodeling in children.</p></div><div><h3>Methods</h3><p>30 pediatric patients were subjected to 12 lead Electrocardiogram immediately before ASD device closure, 24 h post procedure, 1 and 6 months after. The maximum and minimum P wave and QT durations in any of the 12 leads were recorded and P wave and QT dispersions were calculated and compared using paired <em>T</em> test.</p></div><div><h3>Results</h3><p>The immediate 24 h follow up electrocardiogram showed significant decrease in P maximum (140.2 ± 6 versus 130.67 ± 5.4 ms), P dispersion (49.73 ± 9.01 versus 41.43 ± 7.65 ms), PR interval (188.7 ± 6.06 ms versus 182.73 ± 5.8 ms), QRS duration (134.4 ± 4.97 ms versus 127.87 ± 4.44), QT maximum (619.07 ± 15.73 ms versus 613.43 ± 11.87), and QT dispersion (67.6 ± 5.31 versus 62.6 ± 4.68 ms) (P = 0.001). After 1 month all the parameters measured showed further significant decrease with P dispersion reaching 32.13 ± 6 (P = 0.001) and QT dispersion reaching 55.0 ± 4.76 (P = 0.001). These effects were maintained 6 months post device closure.</p></div><div><h3>Conclusion</h3><p>Percutaneous ASD device closure can reverse electrical changes in atrial and ventricular myocardium as early as the first 24 h post device closure.</p></div>","PeriodicalId":44962,"journal":{"name":"Egyptian Heart Journal","volume":"70 4","pages":"Pages 243-247"},"PeriodicalIF":1.4000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehj.2018.02.005","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Heart Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1110260817301849","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 5

Abstract

Background

The beneficial effects of atrial septal defect (ASD) device closure on electrical cardiac remodeling are well established. The timing at which these effects starts to take place has yet to be determined.

Objectives

To determine the immediate and short term effects of ASD device closure on cardiac electric remodeling in children.

Methods

30 pediatric patients were subjected to 12 lead Electrocardiogram immediately before ASD device closure, 24 h post procedure, 1 and 6 months after. The maximum and minimum P wave and QT durations in any of the 12 leads were recorded and P wave and QT dispersions were calculated and compared using paired T test.

Results

The immediate 24 h follow up electrocardiogram showed significant decrease in P maximum (140.2 ± 6 versus 130.67 ± 5.4 ms), P dispersion (49.73 ± 9.01 versus 41.43 ± 7.65 ms), PR interval (188.7 ± 6.06 ms versus 182.73 ± 5.8 ms), QRS duration (134.4 ± 4.97 ms versus 127.87 ± 4.44), QT maximum (619.07 ± 15.73 ms versus 613.43 ± 11.87), and QT dispersion (67.6 ± 5.31 versus 62.6 ± 4.68 ms) (P = 0.001). After 1 month all the parameters measured showed further significant decrease with P dispersion reaching 32.13 ± 6 (P = 0.001) and QT dispersion reaching 55.0 ± 4.76 (P = 0.001). These effects were maintained 6 months post device closure.

Conclusion

Percutaneous ASD device closure can reverse electrical changes in atrial and ventricular myocardium as early as the first 24 h post device closure.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

经皮房间隔缺损装置关闭对儿童心脏电重构的近期和短期影响

背景房间隔缺损(ASD)装置关闭对心脏电重构的有益作用已得到证实。这些影响开始发生的时间还有待确定。目的探讨ASD装置关闭对儿童心脏电重构的近期和短期影响。方法30例患儿在ASD装置关闭前、关闭后24 h、关闭后1、6 个月分别进行12导联心电图检查。记录任意12个导联的最大、最小P波和QT持续时间，计算P波和QT离散度，并采用配对T检验进行比较。24 h ResultsThe立即跟进心电图显示显著降低P最大(140.2 ± 6和130.67 ±5.4  ms), P色散(49.73 ±  9.01和41.43±7.65  ms),公关区间(188.7 ±6.06  女士和182.73 ±5.8  ms), QRS持续时间(134.4 ±4.97  女士和127.87 ±4.44 ),QT最大(619.07 ±15.73  女士和613.43 ±11.87 ),和QT色散(67.6 ±  5.31和62.6±4.68  ms) (P = 0.001)。 1月后所有的参数测量显示进一步明显降低P分散达到32.13 ± 6 (P = 0.001)和QT分散达到55.0 ±4.76 (P = 0.001)。这些效果在器械关闭后维持6 个月。结论经皮ASD装置关闭可在关闭后24 h逆转心房和心室心肌电变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Egyptian Heart Journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Egyptian Heart Journal is the official journal of the Egyptian Society of Cardiology. It is an international journal that publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies and translational investigations. The journal publishes research, review articles, case reports and commentary articles, as well as editorials interpreting and commenting on the research presented. In addition, it provides a forum for the exchange of information on all aspects of cardiovascular medicine, including educational issues.