Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia.

Q2 Medicine BMC Hematology Pub Date : 2019-01-09 eCollection Date: 2019-01-01 DOI:10.1186/s12878-018-0132-1

Absra Solomon, Mintewab Hussein, Mikias Negash, Abdurezak Ahmed, Fitsum Bekele, Daniel Kahase

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引用次数: 28

Abstract

Background: Hemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency Anemia (IDA), will lead to spurious A1C results. Therefore, the present study was aimed at determining the effect of IDA on HbA1c in diabetic patients attending Black Lion Specialized Teaching Hospital, Addis Ababa, Ethiopia.

Methods: A facility based comparative cross sectional study was conducted on 174 diabetic patients (87 with IDA and 87 without IDA) from April to July 2016. Socio demographic data and clinical conditions were collected using structured questionnaire. Venous blood was collected for performing Complete blood count (CBC) using Cell dyn 1800 hematology analyzer; Serum ferritin, performed by COBAS INTEGRA 400/800 Chemistry analyzer and HbA1c tests, performed by COBAS C 111 analyzer. Data was analyzed using SPSS version 21 software. Pearson's correlation, chi-square, and independent t-tests were calculated. The data was presented as mean ± SD. A P-value of < 0.05 was taken as statistically significant.

Results: Mean hemoglobin (Hgb), hematocrit (HCT), Mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC) were lower in IDA group compared to non-IDA diabetic patients. HbA1c (%) level was significantly lower in IDA group (6.18 ± 1.57) compared with the non-IDA diabetic patients (7.74 ± 1.81) (p < 0.05).

Conclusion: HbA1c is significantly lower in diabetic patients with IDA compared to the non-IDA diabetic patients. Therefore, the authors believe that monitoring these patients using only HbA1c could be misleading, hence physicians and health care providers should take this into account before making any therapeutic decision. Detailed examination including large number of participants employing advanced laboratory techniques is recommended.

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埃塞俄比亚亚的斯亚贝巴Tikur Anbessa专科教学医院缺铁性贫血对糖尿病患者HbA1c的影响

背景:糖化血红蛋白(HbA1c)是糖化血红蛋白中主要的血红蛋白。糖化血红蛋白检测是诊断糖尿病的推荐检测方法，任何改变红细胞循环的情况，如缺铁性贫血(IDA)，都会导致伪造的糖化血红蛋白检测结果。因此，本研究旨在确定IDA对埃塞俄比亚亚的斯亚贝巴黑狮专科教学医院糖尿病患者HbA1c的影响。方法:对2016年4 - 7月174例糖尿病患者(合并IDA 87例，未合并IDA 87例)进行基于设备的比较横断面研究。采用结构化问卷法收集社会人口学资料和临床情况。采集静脉血，用Cell dyn 1800血液分析仪测定全血细胞计数(CBC);血清铁蛋白检测采用COBAS INTEGRA 400/800化学分析仪，糖化血红蛋白检测采用COBAS C 111分析仪。数据分析采用SPSS 21版软件。计算Pearson相关检验、卡方检验和独立t检验。数据以mean±SD表示。结果:IDA组平均血红蛋白(Hgb)、红细胞压积(HCT)、平均细胞体积(MCV)、平均细胞血红蛋白(MCH)、平均细胞血红蛋白浓度(MCHC)均低于非IDA组。糖尿病合并IDA组HbA1c(%)水平(6.18±1.57)明显低于非IDA组(7.74±1.81)(p)。结论:糖尿病合并IDA组HbA1c明显低于非IDA组。因此，作者认为仅使用HbA1c监测这些患者可能会产生误导，因此医生和卫生保健提供者在做出任何治疗决定之前应考虑到这一点。建议采用先进的实验室技术进行包括大量参与者在内的详细检查。

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来源期刊

BMC Hematology Medicine-Hematology

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.