Is C. elegans a suitable model for nutritional science?

Abstract

The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the model has a discovery function. Worm research serves also in the identification of nutrition-dependent pathways that could be used for novel approaches in human nutritional studies. This heuristic function of the model guides the applied nutrition research in an innovative direction. Since the nutrition and metabolism for the worm and man differ from each other somewhat strongly, results of nutritional studies in C. elegans are not directly applicable to human nutrition. In general, the C. elegans model is primarily appropriate for explaining the causality of general species' nutritional phenotypes. Experience tells us that the analysis of drastic nutritional phenotypes in C. elegans has the potential to enrich the canon of knowledge of nutritional science.