[Effect of Dengzhan Xxin Injection Dosage on Renal function Using Propensity Score Estimation].

Abstract

Objective To observe clinical dose of Dengzhan Xixin Injection (DZI) on renal func- tion and analyze its relation with abnormal changes of renal function indices [serum creatinine (SCr) and blood urea nitrogen (BUN) ]. Methods The information of 21 498 patients who used DZI were recruited from 20 hospital information system (HIS) database across China. Of them, 13 696 patients in line with 18 -80 years old were taken as subjects. They were assigned to the ultra-dose group ( >40 mL) and the conventional dose group ( ≤40 mL) according to whether the single DZI dosage exceeded the recommended dosage in the drug instruction. Changes of SCr and BUN were taken as outcome evaluation indicators 7 days before and after administration of DZI. There were 650 cases with two SCr values, 87 in the ultra-dose group and 563 in the conventional dose group. There were 651 cases with two BUN values, 87 in the ultra-dose group and 564 in the conventional dose group. Data were analyzed using stratified analysis and propensity score estimation. Results No statistical difference existed in age, gender, admission condi- tion, or stratification estimation results of DZI course between the ultra-dose group. and t6e conventional dose group (P >0. 05). No statistical difference existed in changes of abnormal renal functions between the ultra-dose group and the conventional dose group after balancing 71 confounders factors by propensity score estimation (P >0. 05). Conclusion Analyzed based on HIS data, use of DZI exceeding recommended dosage did not result in abnormal changes of renal function.