[Being Exposed to Specific Syndromes of Chinese Medicine and Being Compatible with Components of Chinese Herbs Are Important Ways to Control Toxicity of Toxic Chinese Herbs].

Abstract

Being exposed to specific syndromes of Chinese medicine (CM) and being compatible with other Chinese herbs are two necessary methods for controlling the toxicity of toxic Chinese herbs. The complexity of Chinese herbal components causes the difficulties in in-depth study of toxicity control. Under the guidance of systems biology, authors studied protein expression profiles and metabolite spec- trums by Chinese herbal compatible components intervening animal model with specific syndrome of CM, thus clarifying corresponding biomarkers relevant to toxicity reducing and control. Authors found out key molecules and pathways for toxicity reducing and control by molecular network technologies using and o- verlaying information integrating. All these mentioned above were finally verified by molecular biologic methods, therefore, revealing the molecular mechanism of toxicity control effects of Chinese herbal compatible components in specific syndromes of CM.