[Effect of Compound Xuanju Capsule on Pregnancy Outcomes of Frozen Embryo Transfer Under- going Release Surgery of Intrauterine Adhesion].

Abstract

Objective To observe the effect of Compound Xuanju Capsule (CXC) on pregnancy outcomes of frozen embryo transfer (FET) undergoing release surgery of intrauterine adhesion (IUA). Methods A total of 300 FET patients with mild to moderate IUA were randomized into the treatment group and the control group, 150 cases in each group. All patients received sequential therapy of estro- gen and progesterone after undergoing release surgery of lUA under hysteroscope. Patients in the treat- ment group additionally took CXC. FET treatment was performed after 3 cycles. Then the embryo implan- tation rate, clinical pregnancy rate, abortion rate, and ectopic pregnancy rate were compared between the two groups. Results The pregnancy rate in the treatment group was higher than that of the control group [47. 3% (71/150) vs. 34. 0% (51/150), P =0. 019]. The embryo implantation rate in the treatment group was 25. 4% (80/315) , higher than that of the control group [19. 6% (61/312) , P =0. 080 ]. The em- bro plantation rate and the clinical embryo implantation rate of moderate IUA patients were lowered, as compared with mild IUA patients in the same group (P < 0. 01, P <0. 05). Compared with the control group, the clinical pregnancy rate was elevated in moderate IUA patients of the treatment group (P < 0. 05). Conclusion CXC could improve endometrial receptivity and elevate the clinical pregnancy rate after undergoing release surgery of IUA.