{"title":"Correction of Copy Number Variation Data Using Principal Component Analysis.","authors":"Jiayu Chen, Jingyu Liu, Vince D Calhoun","doi":"10.1109/BIBMW.2010.5703928","DOIUrl":null,"url":null,"abstract":"<p><p>Copy number variation (CNV) detection using SNP array data is challenging due to the low signal-to-noise ratio. In this study, we propose a principal component analysis (PCA) based correction to eliminate variance in CNV data induced by potential confounding factors. Simulations show a substantial improvement in CNV detection accuracy after correction. We also observe a significant improvement in data quality in real SNP array data after correction.</p>","PeriodicalId":73283,"journal":{"name":"IEEE International Conference on Bioinformatics and Biomedicine workshops. IEEE International Conference on Bioinformatics and Biomedicine","volume":"2010 ","pages":"827-828"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353609/pdf/nihms-1007295.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE International Conference on Bioinformatics and Biomedicine workshops. IEEE International Conference on Bioinformatics and Biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIBMW.2010.5703928","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/1/28 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Copy number variation (CNV) detection using SNP array data is challenging due to the low signal-to-noise ratio. In this study, we propose a principal component analysis (PCA) based correction to eliminate variance in CNV data induced by potential confounding factors. Simulations show a substantial improvement in CNV detection accuracy after correction. We also observe a significant improvement in data quality in real SNP array data after correction.
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