Assessing the Relationship between Performance on the University of California Performance Skills Assessment (UPSA) and Outcomes in Schizophrenia: A Systematic Review and Evidence Synthesis.

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2018-12-27 eCollection Date: 2018-01-01 DOI:10.1155/2018/9075174
Shelagh Szabo, Elizabeth Merikle, Greta Lozano-Ortega, Lauren Powell, Thomas Macek, Stephanie Cline
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引用次数: 5

Abstract

Objective: To perform a systematic review of the published literature to evaluate how functional capacity, as measured by the University of California at San Diego (UCSD) Performance-based Skills Assessment (UPSA), relates to other functional measures and real-world outcomes among individuals with schizophrenia.

Methods: The MEDLINE® and Embase® databases were searched to identify joint evaluations with UPSA and key functional outcomes (functional scale measures; generic or disease-specific, health-related quality of life [HRQoL]; or real-world outcomes [residential status; employment status]) in patients with schizophrenia. Pearson correlations were estimated between UPSA scores, HRQoL, other functional scale measures, and real-world outcomes, for outcomes described in at least six studies.

Results: The synthesis included 76 studies that provided 73 unique data sets. Quantitative assessment between the Specific Level of Function (SLOF) (n=18) scores and UPSA scores demonstrated a moderate borderline-significant correlation (0.45, p=0.06). Quantitative analysis of the relationship between the Global Assessment of Functioning (GAF) (n=11) and the Multidimensional Scale of Independent Functioning (MSIF) (n=6) scales revealed moderate and small nonsignificant Pearson correlations of -0.34 (p=0.31) and 0.12 (p=0.83), respectively. There was a small borderline-significant correlation between UPSA score and residential status (n=36; 0.31; p=0.08), while no correlation was found between UPSA score and employment status (n=19; 0.04; p=0.88).

Conclusion: The SLOF was the most often used functional measure and had the strongest observed correlation with the UPSA. Although knowledge gaps remain, evidence from this review indicates that there is a quantitative relationship between functional capacity and real-world outcomes in individuals with schizophrenia.

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评估加州大学表现技能评估(UPSA)与精神分裂症预后之间的关系:系统回顾和证据综合。
目的:对已发表的文献进行系统回顾,以评估加州大学圣地亚哥分校(UCSD)基于绩效的技能评估(UPSA)所测量的功能能力与精神分裂症患者的其他功能测量和现实世界结果之间的关系。方法:检索MEDLINE®和Embase®数据库,以确定与UPSA和关键功能结局(功能量表测量;一般或疾病特异性、与健康相关的生活质量[HRQoL];或者现实世界的结果[居住状态;精神分裂症患者的就业状况。对于至少六项研究中描述的结果,估计了UPSA评分、HRQoL、其他功能量表测量和现实世界结果之间的Pearson相关性。结果:综合包括76项研究,提供73个独特的数据集。特定功能水平(SLOF)评分(n=18)与UPSA评分之间的定量评估显示中度临界显著相关(0.45,p=0.06)。对整体功能评估(GAF) (n=11)和多维独立功能量表(MSIF) (n=6)量表之间关系的定量分析显示,中度和轻度无显著Pearson相关性分别为-0.34 (p=0.31)和0.12 (p=0.83)。UPSA评分与居住状况之间存在较小的临界显著相关性(n=36;0.31;p=0.08),而UPSA得分与就业状况无相关性(n=19;0.04;p = 0.88)。结论:SLOF是最常用的功能测量,与UPSA的相关性最强。尽管知识差距仍然存在,但本综述的证据表明,精神分裂症患者的功能能力与现实世界的结果之间存在定量关系。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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