Detection of myostatin gene MSTN in some goat breeds (Capra hircus)

IF 3.5 Q3 Biochemistry, Genetics and Molecular Biology Journal of Genetic Engineering and Biotechnology Pub Date : 2018-12-01 DOI:10.1016/j.jgeb.2018.04.002
Y.A. Dowidar , M.A. El-Sayed , Aly M. Elrefy , Hytham E. Shoura
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引用次数: 15

Abstract

Till now not information about myostatin MSTN gene in Egyptian goat breeds. Here we show more information about MSTN in some Egyptian goat breeds to enrich the database with new sequences for Egyptian goat breeds. Our conducted study focused on detection and identifying the MSTN gene as a candidate gene of the muscles growth trait in three goat breeds (Zaraibi, Baladi and Damascus). We found the similarity between the registered sequences with the accession numbers KY463684 for Zaraibi and KY463685 for Baladi and Chinese goat breeds of the MSTN gene deposited with international gene banks by up to 99% and some other species including sheep, cows and bull breeds with percentages of 95 to 97% and between 95 to 99%, respectively. There is also a correlation between the sequences of the registered pieces of Baladi with KY463686 and Damascus and Chinese breeds with KY441464 of MSTN deposited with international gene banks by up to 99% and some other species including sheep and bull breeds at a ratio of 99% for two pieces. Results demonstrated the deposited sequences of object are part of intron 1, exon 2 is fully sequenced with Zaraibi and Baladi breeds; the intron 1, exon 1 with Baladi breed; and the intron 2, part of exon 3 with Damascus breed. Therefore, the Egyptian goat breeds consider national wealth can be used to develop breeding and improvement programs which helps in more applicable scopes like biotechnology, genetic engineering and molecular biology with the help of bioinformatics tools.

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部分山羊品种肌肉生长抑制素基因MSTN的检测
到目前为止,还没有关于埃及山羊品种肌肉生长抑制素MSTN基因的信息。在这里,我们展示了一些埃及山羊品种的MSTN的更多信息,以丰富埃及山羊品种的新序列数据库。我们的研究重点是检测和鉴定MSTN基因作为三个山羊品种(Zaraibi, Baladi和Damascus)肌肉生长性状的候选基因。结果发现,国际基因库中存放的MSTN基因在扎来比品种的KY463684、巴拉迪品种的KY463685和中国山羊品种的KY463685中,与绵羊品种、奶牛品种和公牛品种的95% ~ 97%和95% ~ 99%之间的相似性高达99%。Baladi与KY463686和Damascus的已登记片段与中国品种的KY441464的序列之间的相关性高达99%,而其他一些物种(包括羊和牛品种)的序列之间的相关性高达99%。结果表明,所沉积的对象序列为1号内含子的一部分,2号外显子与扎莱比和巴拉迪品种完全测序;内含子1、外显子1与巴拉迪品种有关;内含子2是大马士革品种的外显子3的一部分。因此,埃及山羊品种认为可以利用国家财富制定育种和改良计划,这有助于在生物信息学工具的帮助下,在更适用的范围内,如生物技术、基因工程和分子生物学。
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来源期刊
Journal of Genetic Engineering and Biotechnology
Journal of Genetic Engineering and Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
5.70
自引率
5.70%
发文量
159
审稿时长
16 weeks
期刊介绍: Journal of genetic engineering and biotechnology is devoted to rapid publication of full-length research papers that leads to significant contribution in advancing knowledge in genetic engineering and biotechnology and provide novel perspectives in this research area. JGEB includes all major themes related to genetic engineering and recombinant DNA. The area of interest of JGEB includes but not restricted to: •Plant genetics •Animal genetics •Bacterial enzymes •Agricultural Biotechnology, •Biochemistry, •Biophysics, •Bioinformatics, •Environmental Biotechnology, •Industrial Biotechnology, •Microbial biotechnology, •Medical Biotechnology, •Bioenergy, Biosafety, •Biosecurity, •Bioethics, •GMOS, •Genomic, •Proteomic JGEB accepts
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