Tendon healing in the context of complex fractures.

IF 0.8 Q4 ENDOCRINOLOGY & METABOLISM Clinical Reviews in Bone and Mineral Metabolism Pub Date : 2018-12-01 Epub Date: 2018-12-29 DOI:10.1007/s12018-018-9254-z
Elahe Ganji, Megan L Killian
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引用次数: 3

Abstract

Tendons connect muscle to bone and play an integral role in bone and joint alignment and loading. Tendons act as pulleys that provide anchorage of muscle forces for joint motion and stability, as well as for fracture reduction and realignment. Patients that experience complex fractures also have concomitant soft tissue injuries, such as tendon damage or rupture. Tendon injuries that occur at the time of bone fracture have long-term ramifications on musculoskeletal health, yet these injuries are often disregarded in clinical treatment and diagnosis for patients with bone fractures as well as in basic science approaches for understanding bone repair processes. Delayed assessment of soft tissue injuries during evaluation of trauma can lead to chronic pain, dysfunction, and delayed bone healing even following successful fracture repair, highlighting the importance of identifying and treating damaged tendons early. Treatment strategies for bone repair, such as mechanical stabilization and biological therapeutics, can impact tendon healing and function. Because poor tendon healing following complex fracture can significantly impact the function of tendon during bone fracture healing, a need exists to understand the healing process of complex fractures more broadly, beyond the healing of bone. In this review, we explored the mechanical and biological interaction of bone and tendon in the context of complex fracture, as well as the relevance and potential ramifications of tendon damage following bone fracture, which has particular impact on patients that experience complex fractures, such as from combat, automobile accidents, and other trauma.

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复杂骨折情况下的肌腱愈合。
肌腱连接肌肉和骨骼,在骨骼和关节的对齐和负载中发挥着不可或缺的作用。肌腱充当滑轮,为关节运动和稳定性以及骨折复位和重新调整提供肌肉力量的锚定。经历复杂骨折的患者也会伴随软组织损伤,如肌腱损伤或断裂。骨折时发生的肌腱损伤对肌肉骨骼健康有长期影响,但在骨折患者的临床治疗和诊断以及了解骨修复过程的基础科学方法中,这些损伤往往被忽视。创伤评估过程中对软组织损伤的延迟评估可能导致慢性疼痛、功能障碍和骨愈合延迟,即使在骨折修复成功后也是如此,这突出了早期识别和治疗受损肌腱的重要性。骨修复的治疗策略,如机械稳定和生物治疗,可以影响肌腱的愈合和功能。由于复杂骨折后肌腱愈合不良会严重影响肌腱在骨折愈合过程中的功能,因此需要更广泛地了解复杂骨折的愈合过程,而不仅仅是骨的愈合。在这篇综述中,我们探讨了复杂骨折中骨和肌腱的机械和生物相互作用,以及骨折后肌腱损伤的相关性和潜在后果,这对经历复杂骨折的患者有特别的影响,如战斗、车祸和其他创伤。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
2
期刊介绍: Clinical Reviews in Bone and Mineral Metabolism is an international review journal aimed at integrating new information from both basic and clinical science into the context of clinical practice in the wide field of Bone and Mineral Metabolism. Although one purpose of the journal is to deal with the well-known classical aspects of bone and mineral physiology, the journal’s unique character is to highlight information about the advancing field of molecular medicine, which now finds linkages between this classical field and disease states that in the past were considered distinct. For example, cardiovascular disease and osteoporosis share many biochemical pathways. New molecular tools show common pathways with bone physiology and obesity, diabetes mellitus, and energy metabolism. The focus on the novel is a major aspect of this journal’s purpose. The rapid developments in the field needs to be represented in a comprehensive way in order to keep students, clinicians and researchers up-to date. In order to assure that all latest developments are covered, the journal publishes, not only, unsolicited reviews, but also invited reviews on most important topics as well.
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