{"title":"Tendon healing in the context of complex fractures.","authors":"Elahe Ganji, Megan L Killian","doi":"10.1007/s12018-018-9254-z","DOIUrl":null,"url":null,"abstract":"<p><p>Tendons connect muscle to bone and play an integral role in bone and joint alignment and loading. Tendons act as pulleys that provide anchorage of muscle forces for joint motion and stability, as well as for fracture reduction and realignment. Patients that experience complex fractures also have concomitant soft tissue injuries, such as tendon damage or rupture. Tendon injuries that occur at the time of bone fracture have long-term ramifications on musculoskeletal health, yet these injuries are often disregarded in clinical treatment and diagnosis for patients with bone fractures as well as in basic science approaches for understanding bone repair processes. Delayed assessment of soft tissue injuries during evaluation of trauma can lead to chronic pain, dysfunction, and delayed bone healing even following successful fracture repair, highlighting the importance of identifying and treating damaged tendons early. Treatment strategies for bone repair, such as mechanical stabilization and biological therapeutics, can impact tendon healing and function. Because poor tendon healing following complex fracture can significantly impact the function of tendon during bone fracture healing, a need exists to understand the healing process of complex fractures more broadly, beyond the healing of bone. In this review, we explored the mechanical and biological interaction of bone and tendon in the context of complex fracture, as well as the relevance and potential ramifications of tendon damage following bone fracture, which has particular impact on patients that experience complex fractures, such as from combat, automobile accidents, and other trauma.</p>","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"16 4","pages":"131-141"},"PeriodicalIF":0.8000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-018-9254-z","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Reviews in Bone and Mineral Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12018-018-9254-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/12/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 3
Abstract
Tendons connect muscle to bone and play an integral role in bone and joint alignment and loading. Tendons act as pulleys that provide anchorage of muscle forces for joint motion and stability, as well as for fracture reduction and realignment. Patients that experience complex fractures also have concomitant soft tissue injuries, such as tendon damage or rupture. Tendon injuries that occur at the time of bone fracture have long-term ramifications on musculoskeletal health, yet these injuries are often disregarded in clinical treatment and diagnosis for patients with bone fractures as well as in basic science approaches for understanding bone repair processes. Delayed assessment of soft tissue injuries during evaluation of trauma can lead to chronic pain, dysfunction, and delayed bone healing even following successful fracture repair, highlighting the importance of identifying and treating damaged tendons early. Treatment strategies for bone repair, such as mechanical stabilization and biological therapeutics, can impact tendon healing and function. Because poor tendon healing following complex fracture can significantly impact the function of tendon during bone fracture healing, a need exists to understand the healing process of complex fractures more broadly, beyond the healing of bone. In this review, we explored the mechanical and biological interaction of bone and tendon in the context of complex fracture, as well as the relevance and potential ramifications of tendon damage following bone fracture, which has particular impact on patients that experience complex fractures, such as from combat, automobile accidents, and other trauma.
期刊介绍:
Clinical Reviews in Bone and Mineral Metabolism is an international review journal aimed at integrating new information from both basic and clinical science into the context of clinical practice in the wide field of Bone and Mineral Metabolism. Although one purpose of the journal is to deal with the well-known classical aspects of bone and mineral physiology, the journal’s unique character is to highlight information about the advancing field of molecular medicine, which now finds linkages between this classical field and disease states that in the past were considered distinct. For example, cardiovascular disease and osteoporosis share many biochemical pathways. New molecular tools show common pathways with bone physiology and obesity, diabetes mellitus, and energy metabolism. The focus on the novel is a major aspect of this journal’s purpose. The rapid developments in the field needs to be represented in a comprehensive way in order to keep students, clinicians and researchers up-to date. In order to assure that all latest developments are covered, the journal publishes, not only, unsolicited reviews, but also invited reviews on most important topics as well.