Glucose Lowering Activity of Aqueous Ammodaucus leucotrichus Extract in Diabetic Rats.

Q2 Medicine Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2020-01-01 DOI:10.2174/1871529X19666190222182312

Fadwa El-Ouady, Mohamed Eddouks

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引用次数: 5

Abstract

Background: Ammodaucus leucotrichus (Apiaceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes.

Aims: The aim of this study was to evaluate the antidiabetic effect of the aqueous extract prepared from the fruits of this medicinal plant. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of Ammodaucus leucotrichus (A. leucotrichus) at a dose of 10 mg/kg.

Methods: The blood glucose levels were determined during 6 hours and 15 days during this treatment. In addition the oral glucose tolerance test as well as the analysis of histopathological changes of liver was performed. The antioxidant activity of aqueous A. Leucotrichus extract was also valuated by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH).

Results: A. Leucotrichus fruit aqueous extract (ALFAE) reduced the blood glucose levels in both normal and diabetic rats. In addition, a remarkable influence on glucose tolerance was also noticed after ALFAE treatment. Moreover, ALFAE was able to exhibit a beneficial effect on histologlogical structure of liver. Finally a potential antioxidant effect has been shown in vitro.

Conclusion: In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of A. Leucotrichus in rats supporting then its traditional use for the management of diabetes.

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白毛杉水提物对糖尿病大鼠降血糖活性的研究。

背景:凤尾花(Ammodaucus leucotrichus)是一种药用植物，被摩洛哥人广泛用于治疗包括糖尿病在内的各种疾病。目的:评价该药用植物果实水提物的抗糖尿病作用。采用10 mg/kg剂量的白毛杉提取物口服治疗正常及链脲佐菌素诱导的糖尿病大鼠。方法:分别于治疗期间6 h和15 d测定血糖水平。同时进行口服糖耐量试验和肝脏组织病理变化分析。采用吸附自由基2,2-二苯基-1苦酰肼(DPPH)的方法评价了白桦水提物的抗氧化活性。结果:A.白三毛果水提物(ALFAE)降低了正常和糖尿病大鼠的血糖水平。此外，ALFAE治疗对糖耐量也有显著影响。此外，ALFAE能够对肝脏的组织结构产生有益的影响。最后，体外实验显示出潜在的抗氧化作用。结论:总之，本研究证明了白桦对大鼠的降糖和降糖作用，支持了其治疗糖尿病的传统用途。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

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期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.