Stem cells: past, present, and future.

IF 4.4 2区 化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Polymer Materials Pub Date : 2019-02-26 DOI:10.1186/s13287-019-1165-5
Wojciech Zakrzewski, Maciej Dobrzyński, Maria Szymonowicz, Zbigniew Rybak
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Abstract

In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and derivation. Quality control and teratoma formation assays are important procedures in assessing the properties of the stem cells tested. Derivation methods and the utilization of culturing media are crucial to set proper environmental conditions for controlled differentiation. Among many types of stem tissue applications, the use of graphene scaffolds and the potential of extracellular vesicle-based therapies require attention due to their versatility. The review is summarized by challenges that stem cell therapy must overcome to be accepted worldwide. A wide variety of possibilities makes this cutting edge therapy a turning point in modern medicine, providing hope for untreatable diseases.

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干细胞:过去、现在和未来。
近年来,干细胞治疗已成为一个非常有前景的先进科研课题。治疗方法的发展令人充满期待。本文综述了不同干细胞的发现以及基于这些细胞的潜在疗法。在介绍干细胞的起源之后,介绍了干细胞受控培养和衍生的实验室步骤。质量控制和畸胎瘤形成试验是评估受测干细胞特性的重要程序。衍生方法和培养基的使用对于为受控分化设定适当的环境条件至关重要。在多种干组织应用中,石墨烯支架的使用和基于细胞外囊泡疗法的潜力因其多功能性而备受关注。综述总结了干细胞疗法必须克服的挑战,才能被全世界接受。多种可能性使这种尖端疗法成为现代医学的转折点,为无法治疗的疾病带来希望。
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来源期刊
CiteScore
7.20
自引率
6.00%
发文量
810
期刊介绍: ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.
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