Behavioral models in psychopathology: epistemic and semantic considerations.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2019-03-01 DOI:10.1186/s12993-019-0152-4
Caio Maximino, Franz Josef van der Staay
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引用次数: 20

Abstract

The use of animals in neurosciences has a long history. It is considered indispensable in areas in which "translational" research is deemed invaluable, such as behavioral pharmacology and comparative psychology. Animal models are being used in pharmacology and genetics to screen for treatment targets, and in the field of experimental psychopathology to understand the neurobehavioral underpinnings of a disorder and of its putative treatment. The centrality of behavioral models betrays the complexity of the epistemic and semantic considerations which are needed to understand what a model is. In this review, such considerations are made, and the breadth of model building and evaluation approaches is extended to include theoretical considerations on the etiology of mental disorders. This expansion is expected to help improve the validity of behavioral models and to increase their translational value. Moreover, the role of theory in improving construct validity creates the need for behavioral scientists to fully engage this process.

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精神病理学中的行为模型:认识论和语义考虑。
在神经科学中使用动物已有很长的历史。在行为药理学和比较心理学等“转化”研究被认为是无价的领域,它被认为是不可或缺的。动物模型被用于药理学和遗传学领域,以筛选治疗目标,并在实验精神病理学领域,以了解疾病的神经行为基础及其假定的治疗方法。行为模型的中心性暴露了理解模型所需要的认知和语义考虑的复杂性。在这篇综述中,这些考虑是作出的,并扩大了模型建立和评估方法的广度,包括对精神障碍病因的理论考虑。这种扩展预计将有助于提高行为模型的有效性,并增加其翻译价值。此外,理论在提高构念效度方面的作用使得行为科学家需要充分参与这一过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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