Pregnancy Immunogenetics and Genomics: Implications for Pregnancy-Related Complications and Autoimmune Disease.

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY Annual review of genomics and human genetics Pub Date : 2019-08-31 Epub Date: 2019-03-08 DOI:10.1146/annurev-genom-083118-014943
Hing-Yuen Yeung, Calliope A Dendrou
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引用次数: 17

Abstract

Pregnancy presents a singular physiological scenario during which the maternal immune system must accommodate the semiallogeneic fetus. Fluctuations between pro- and anti-inflammatory states are required throughout gestation to facilitate uterine tissue remodeling, fetal growth and development, and finally birth. Tolerance for the fetus must be established and maintained without fundamentally compromising the maternal immune system function, so that both the mother and fetus are protected from foreign insults. Here, we review our current understanding of how genetic variation at both maternal and fetal loci affects implantation and placenta formation, thereby determining the likelihood of a successful pregnancy outcome or the development of pregnancy-related complications. We also consider the impact of pregnancy on both the maternal and fetal systemic immune systems and the related implications for modulating ongoing autoimmune diseases and triggering their development.

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妊娠免疫遗传学和基因组学:妊娠相关并发症和自身免疫性疾病的含义。
怀孕期间,母体免疫系统必须适应半异体胎儿,这是一种奇特的生理情况。在整个妊娠期间,促炎和抗炎状态之间需要波动,以促进子宫组织重塑、胎儿生长发育和最终出生。必须在不从根本上损害母体免疫系统功能的情况下建立和维持对胎儿的耐受性,从而保护母亲和胎儿免受外来侵害。在这里,我们回顾了我们目前对母体和胎儿基因座的遗传变异如何影响着床和胎盘形成的理解,从而决定了成功妊娠结局或妊娠相关并发症发生的可能性。我们还考虑了怀孕对母体和胎儿全身免疫系统的影响,以及对正在进行的自身免疫性疾病的调节和触发其发展的相关含义。
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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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