Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus.

IF 3.1 Q2 MICROBIOLOGY Current Clinical Microbiology Reports Pub Date : 2018-12-01 Epub Date: 2018-08-03 DOI:10.1007/s40588-018-0102-1

Matthew Butnaru, Marta M Gaglia

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引用次数: 3

Abstract

Purpose of review: Kaposi's sarcoma-associated herpesvirus (KSHV), the etiological agent of the AIDS-associated tumor Kaposi's sarcoma, is a complex virus that expresses ~90 proteins in a regulated temporal cascade during its replication cycle. Although KSHV relies on cellular machinery for gene expression, it also uses specialized regulators to control nearly every step of the process. In this review we discuss the current understanding of KSHV gene regulation.

Recent findings: High-throughput sequencing and a new robust system to mutate KSHV have paved the way for comprehensive studies of KSHV gene expression, leading to the characterization of new viral factors that control late gene expression and post-transcriptional steps of gene regulation. They have also revealed key aspects of chromatin-based control of gene expression in the latent and lytic cycle.

Summary: The combination of mutant analysis and high-throughput sequencing will continue to expand our model of KSHV gene regulation and point to potential new targets for anti-KSHV drugs.

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γ -疱疹病毒卡波西肉瘤相关疱疹病毒病毒基因表达的转录和转录后调控

综述目的:卡波西肉瘤相关疱疹病毒(KSHV)是艾滋病相关肿瘤卡波西肉瘤的病原，是一种复杂的病毒，在其复制周期中以受调节的时间级联表达约90种蛋白。尽管KSHV依赖于细胞机制来进行基因表达，但它也使用专门的调节因子来控制过程的几乎每一步。在这篇综述中，我们讨论了目前对KSHV基因调控的理解。最近的发现:高通量测序和一种新的强大的KSHV突变系统为KSHV基因表达的全面研究铺平了道路，导致了控制晚期基因表达和基因调控转录后步骤的新病毒因子的表征。他们还揭示了在潜伏和裂解循环中染色质为基础的基因表达控制的关键方面。突变体分析和高通量测序的结合将继续扩展我们的KSHV基因调控模型，并指出抗KSHV药物的潜在新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.