Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic.

Peggy L Carver
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引用次数: 7

Abstract

Metal ions are indispensable for living organisms. However, the roles of metal ions in humans is complex, and remains poorly understood. Imbalances in metal ion levels, due to genetic or environmental sources, are associated with a number of significant health issues. However, in clinical medicine, the role of metal ions and metal-based drugs is notable in three major areas: as metal-related diseases; as metal-based medicines (including drugs, imaging agents, and metal chelators); and as agents of metal-based toxicity.

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医学中的金属:金属离子在临床中的治疗用途。
金属离子对生物体是不可缺少的。然而,金属离子在人体中的作用是复杂的,并且仍然知之甚少。由于遗传或环境原因导致的金属离子水平失衡与许多重大健康问题有关。然而,在临床医学中,金属离子和金属基药物在三个主要领域的作用是显著的:作为金属相关疾病;作为金属基药物(包括药物、显像剂和金属螯合剂);作为金属毒性的媒介。
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Introduction: Transition Metals and Sulfur. Sulfur, the Versatile Non-metal. The Type 1 Blue Copper Site: From Electron Transfer to Biological Function. Purple Mixed-Valent Copper A. The Tetranuclear Copper-Sulfide Center of Nitrous Oxide Reductase.
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