Molecular Allergy Diagnostics as an Adjunct to Conventional Diagnostics in a Secondary Pediatric Referral Center.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics Recent patents on inflammation & allergy drug discovery Pub Date : 2019-01-01 DOI:10.2174/1872213X13666190610143439
Ole D Wolthers
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引用次数: 1

Abstract

Background: Several compositions for determination of specific molecular components in allergens have recently been patented. The role of Molecular Allergy (MA) diagnostics in suspected IgE mediated allergic conditions is currently debated. Guideline reports have concluded that population- based studies involving evaluation of the usefulness of MA diagnostics are needed.

Objective: To evaluate the usefulness of MA diagnostics in a secondary pediatric referral center.

Methods: A total of 961 children and adolescents aged 0.2-18.8 (mean 7.0) years was included in a prospective observational survey. Inclusion criterion was a suspected diagnosis of an IgE mediated condition based on history and clinical symptoms and signs. If a specific diagnosis could not be reached from conventional investigations suspected peanut allergy, birch pollen allergy and associated crossreactivity, insect allergy and triggering allergens for specific immunotherapy were assessed by MA diagnostics.

Results: Based on conventional work-up a diagnostic conclusion was established in 946 patients (98.4%). MA diagnostics were performed in 15 individuals (1.6%), 7 girls and 8 boys aged 3.2 to 17.8 (mean 10.6) years. In 8 cases a specific diagnosis was established based on MA diagnostics; in 7 cases MA diagnostics could not improve diagnosis. MA were most frequently (N = 7 (14%)) used in children with peanut allergy (N = 50).

Conclusion: Most patients in a secondary pediatric referral center with suspected IgE mediated allergy can be managed by conventional diagnostic methods. MA diagnostics may be useful in small and selected subgroups as in patients with suspected peanut allergy, however, may not be helpful in all cases.

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分子过敏诊断作为辅助常规诊断在二级儿科转诊中心。
背景:几种用于测定过敏原中特定分子成分的组合物最近获得了专利。分子过敏(MA)诊断在疑似IgE介导的过敏条件中的作用目前存在争议。指南报告的结论是,有必要开展以人群为基础的研究,评估MA诊断的有效性。目的:评价二级儿科转诊中心MA诊断的有效性。方法:对961名年龄在0.2-18.8岁(平均7.0岁)的儿童和青少年进行前瞻性观察性调查。纳入标准是基于病史和临床症状和体征的疑似IgE介导疾病的诊断。如果常规调查无法得出特异性诊断,则采用MA诊断评估特异性免疫治疗的疑似花生过敏、桦木花粉过敏及相关交叉反应、昆虫过敏和触发过敏原。结果:946例患者(98.4%)在常规检查的基础上得出诊断结论。15人(1.6%)进行了MA诊断,7名女孩和8名男孩,年龄为3.2至17.8岁(平均10.6岁)。在8例中,基于MA诊断建立了特定的诊断;7例MA诊断不能提高诊断。花生过敏儿童(N = 50)最常使用MA (N = 7(14%))。结论:在二级儿科转诊中心,大多数疑似IgE介导的过敏患者可以通过常规诊断方法进行治疗。MA诊断可能对小的和选定的亚组有用,如疑似花生过敏的患者,然而,可能不是对所有病例都有帮助。
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CiteScore
3.90
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期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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Meet Our Editorial Board Member Diagnosis of Allergic Reactions to Drugs Non-steroidal Anti-inflammatory Drugs Other Antimicrobial Drugs Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones
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