Association of IL-12 and TNF-α Polymorphisms with Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients.

IF 0.3 Q4 TRANSPLANTATION International Journal of Organ Transplantation Medicine Pub Date : 2019-01-01 Epub Date: 2019-02-01

M H Karimi, S Salek, R Yaghobi, M Ramzi, B Geramizadeh, F Kafilzadeh

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Abstract

Background: Cytokines are important factors determining the outcome of transplantation. The host ability in cytokine production may be affected by cytokine genes polymorphisms.

Objective: To investigate the effect of IL-12 and TNF-α gene polymorphisms on outcome of hematopoietic stem cell transplantation.

Methods: 90 bone marrow transplant recipients were included in this study. 30 (33%) of 90 recipients experienced graft-versus-host disease (GVHD). IL-12 and TNF-α gene polymorphisms were evaluated by PCR-RFLP and ARMS-PCR method, respectively.

Results: No significant difference in the distribution of IL-12 (rs3212227 +1188 A/C) and TNF-α (rs 1800629 -308 G/A) genotypes and alleles was observed between those with and without GVHD. There was no significant association between the distribution of genotypes and the recipient sex.

Conclusion: IL-12 (rs3212227 +1188 A/C) and TNF-α (rs 1800629-308 G/A) genotypes and alleles were not risk factors for development of GVHD.

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异基因造血干细胞移植受者IL-12和TNF-α多态性与移植物抗宿主病的关系

背景:细胞因子是决定移植预后的重要因素。宿主产生细胞因子的能力可能受到细胞因子基因多态性的影响。目的:探讨IL-12和TNF-α基因多态性对造血干细胞移植预后的影响。方法:90例骨髓移植受者为研究对象。90名受者中有30名(33%)经历了移植物抗宿主病(GVHD)。采用PCR-RFLP法和ARMS-PCR法分别检测IL-12和TNF-α基因多态性。结果:血清IL-12 (rs3212227 +1188 A/C)和TNF-α (rs1800629 -308 G/A)基因型和等位基因在GVHD患者和非GVHD患者中的分布无显著差异。基因型分布与受体性别无显著相关性。结论:IL-12 (rs3212227 +1188 A/C)和TNF-α (rs1800629 -308 G/A)基因型和等位基因不是GVHD发生的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Organ Transplantation Medicine TRANSPLANTATION-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.