Transcranial magnetic stimulation therapy for focal leg dystonia: a case report.

Journal of Clinical Movement Disorders Pub Date : 2019-03-08 eCollection Date: 2019-01-01 DOI:10.1186/s40734-019-0076-z

Kush Sharma, Alberto Cucca, Andrea Lee, Shashank Agarwal, Steven Joel Frucht, Milton Cesar Biagioni

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引用次数: 5

Abstract

Background: Dystonia is a debilitating disease that causes abnormal, often repetitive, movements, postures or both. The pathophysiology is unknown but related to loss of neuronal inhibition, aberrant sensorimotor integration, and/or derangements of synaptic plasticity. Current treatments include pharmacotherapy, botulinum toxin injections and deep brain stimulation (DBS). The response to these treatments are often limited and carry the risk of side effects requiring alternative therapies such as non-invasive brain stimulation.

Case presentation: We present a case report of a 65-year -old man with refractory focal 'task-specific' dystonia. The treatment plan included 10-daily sessions of 1 Hz, 2600 pulses of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex.

Conclusion: There were no clinical benefits noticed. Currently, there are no rTMS protocol treatments for dystonia. Publication of negative results will help in refining the optimal stimulation parameters, thus maximizing the effectiveness and reproducibility of future therapeutic protocols.

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经颅磁刺激治疗局灶性腿肌张力障碍1例。

背景:肌张力障碍是一种使人衰弱的疾病，可引起异常的、经常重复的运动、姿势或两者兼而有之。其病理生理机制尚不清楚，但与神经元抑制丧失、感觉运动整合异常和/或突触可塑性紊乱有关。目前的治疗方法包括药物治疗、肉毒杆菌毒素注射和深部脑刺激(DBS)。对这些治疗的反应通常是有限的，并且有副作用的风险，需要非侵入性脑刺激等替代疗法。病例报告:我们报告一个65岁男性难治性局灶性“任务特异性”肌张力障碍的病例报告。治疗计划包括每天10次的1赫兹，2600脉冲的重复经颅磁刺激(rTMS)，目标是初级运动皮层。结论:无临床获益。目前，没有rTMS方案治疗肌张力障碍。发表阴性结果将有助于完善最佳刺激参数，从而最大限度地提高未来治疗方案的有效性和可重复性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Clinical Movement Disorders

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