Evaluation of Adverse Reactions Induced by Anti-Tuberculosis Drugs in Hospital Pulau Pinang.

IF 1.5 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Malaysian Journal of Medical Sciences Pub Date : 2018-09-01 Epub Date: 2018-10-30 DOI:10.21315/mjms2018.25.5.10

Cheah Meng Fei, Hadzliana Zainal, Irfhan Ali Hyder Ali

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引用次数: 10

Abstract

Background: The use of multi-drug regimens in tuberculosis (TB) treatment has been associated with undesirable adverse drug reactions (ADRs). This study aims to assess the incidence and impact of ADRs on TB treatment in Hospital Pulau Pinang.

Methods: This cross-sectional study was conducted via retrospective review of outpatients' medical records. Details regarding ADRs were identified by a pharmacist and verified by a consultant respiratory physician.

Results: A total of 91 cases, out of 210 patients enrolled in this study, were detected with 75 patients (35.7%) experienced at least one ADR. The three most common ADRs detected were cutaneous adverse drug reactions (CADRs) (21.0%), drug-induced hepatitis (DIH) (7.1%) and gastrointestinal disturbance (4.8%). Pyrazinamide was the most common causative agent and 15.7% of all TB patients required treatment modification due to ADRs. Females were shown to have a higher tendency to develop ADRs than the males in this study (P = 0.009). The development of ADRs was shown not to affect the TB treatment outcomes (P = 0.955).

Conclusion: The incidence of ADRs in this study was high so it is important to identify the risk factors for ADRs and the individuals who have those risk factors when initiating anti-TB drugs. These individuals require special attention when anti-TB drugs are initiated.

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槟榔屿医院抗结核药物不良反应评价。

背景:在结核病(TB)治疗中使用多药方案与不良药物反应(adr)有关。本研究旨在评估槟榔屿医院结核病药物不良反应的发生率及对结核病治疗的影响。方法:采用回顾性分析门诊病历的方法进行横断面研究。有关不良反应的细节由药剂师确定，并由呼吸内科顾问医生核实。结果:在210例入组患者中，共检测到91例，其中75例(35.7%)至少发生了一次ADR。最常见的3种不良反应是皮肤药物不良反应(CADRs)(21.0%)、药物性肝炎(DIH)(7.1%)和胃肠道紊乱(4.8%)。吡嗪酰胺是最常见的病原体，15.7%的结核病患者因不良反应需要修改治疗方案。本研究显示，女性发生不良反应的倾向高于男性(P = 0.009)。不良反应的发生不影响结核治疗结果(P = 0.955)。结论:本研究中adr的发生率较高，因此在开始使用抗结核药物时，确定adr的危险因素和存在这些危险因素的个体是重要的。这些人在开始使用抗结核药物时需要特别注意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Journal of Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access, fully online journal that is published at least six times a year. The journal’s scope encompasses all aspects of medical sciences including biomedical, allied health, clinical and social sciences. We accept high quality papers from basic to translational research especially from low & middle income countries, as classified by the United Nations & World Bank (https://datahelpdesk.worldbank.org/knowledgebase/ articles/906519), with the aim that published research will benefit back the bottom billion population from these countries. Manuscripts submitted from developed or high income countries to MJMS must contain data and information that will benefit the socio-health and bio-medical sciences of these low and middle income countries. The MJMS editorial board consists of internationally regarded clinicians and scientists from low and middle income countries.