Development of the hematopoietic system: Role of inflammatory factors.

Q1 Biochemistry, Genetics and Molecular Biology Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2019-07-01 Epub Date: 2019-03-27 DOI:10.1002/wdev.341
Yoshikazu Hayashi, Maiko Sezaki, Hitoshi Takizawa
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引用次数: 8

Abstract

Hematopoietic stem cells (HSCs) have two defining features, multipotency and self-renewal, both of which are tightly controlled by cell autonomous programs and environmental factors throughout the lifetime of an organism. During development, HSCs are born in the aorta-gonad-mesonephros region, and migrate to distinct hematopoietic organs such as the placenta, fetal liver and spleen, continuously self-renewing and expanding to reach a homeostatic number. HSCs ultimately seed the bone marrow around the time of birth and become dormant to sustain lifelong hematopoiesis. In this review, we will summarize the recent findings on the role of inflammatory factors regulating HSC development, that is, emergence, trafficking and differentiation. An understanding of HSC kinetics during developmental processes will provide useful knowledge on HSC behavior under physiological and pathophysiological conditions. This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Adult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells.

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造血系统的发展:炎症因子的作用。
造血干细胞(Hematopoietic stem cells, hsc)具有多能性(multipotency)和自我更新(self-renewal)两大特征,这两大特征在生物体的整个生命周期中都受到细胞自主程序和环境因素的严格控制。造血干细胞在发育过程中出生在主动脉-性腺-中肾区,并迁移到不同的造血器官,如胎盘、胎肝和脾,不断自我更新和扩大,达到稳态数量。造血干细胞最终在出生时植入骨髓,并进入休眠状态以维持终身造血。在本文中,我们将对近年来炎症因子在调节HSC发生、运输和分化方面的研究进展进行综述。了解发育过程中的HSC动力学将为生理和病理生理条件下的HSC行为提供有用的知识。本文分类如下:成体干细胞,组织更新和再生>再生成体干细胞,组织更新和再生>组织干细胞和壁龛成体干细胞,组织更新和再生>干细胞的环境控制。
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期刊介绍: Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.
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