Is asthma in the elderly different? Functional and clinical characteristics of asthma in individuals aged 65 years and older.

Asthma research and practice Pub Date : 2019-03-19 eCollection Date: 2019-01-01 DOI:10.1186/s40733-019-0049-x

Elena Curto, Astrid Crespo-Lessmann, María Victoria González-Gutiérrez, Santiago Bardagí, Concepción Cañete, Concha Pellicer, Teresa Bazús, María Del Carmen Vennera, Carlos Martínez, Vicente Plaza

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Abstract

Background: The prevalence of chronic diseases in the elderly (> 65 years), including asthma, is growing, yet information available on asthma in this population is scarce.Our objective is to determine the differential clinical and functional characteristics of the population > 65 years old with asthma included in the Integrated Research Programs of Asthma Databank of the Spanish Society of Pneumology and Thoracic Surgery (www.bancodatosasma.com).

Methods: Retrospective comparative descriptive study of demographic, clinical and functional variables for 1713 patients with asthma categorized into 3 age groups as follows: adults aged < 65 years (A), younger elderly aged 65-74 years (B) and older elderly aged ≥75 years (C).

Results: Predominant features of elderly patients with asthma (N = 471) were the female sex, fewer smokers, greater obesity, poorer lung function, and lower values of nitric oxide in exhaled air (p < 0.01). The most frequently associated comorbidity was gastroesophageal reflux. The highest doses of inhaled corticosteroids were by group A (60.8%). For the sample overall, 23.2% (N = 398) were being treated with omalizumab and 8.2% (N = 140) were corticosteroid-dependent (10.6% in group B). The highest percentage of patients receiving antileukotriene agents was in group B (42.9%).

Conclusions: Asthma in adults aged> 65 is more severe and associated with greater comorbidity, which would indicate the need for a more integrated and multidimensional approach to asthma treatment for these patients.

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老年人的哮喘有什么不同吗？65 岁及以上老年人哮喘的功能和临床特征。

背景：包括哮喘在内的慢性病在老年人（65 岁以上）中的发病率正在上升，但有关这一人群哮喘的信息却很少。我们的目的是确定西班牙肺病和胸外科学会哮喘综合研究计划数据库（www.bancodatosasma.com）中 65 岁以上哮喘患者的不同临床和功能特征：方法：对 1713 名哮喘患者的人口统计学、临床和功能变量进行回顾性比较描述性研究，分为以下 3 个年龄组：成人、65 岁和 65 岁：老年哮喘患者（N = 471）的主要特征是女性、吸烟者较少、肥胖程度较高、肺功能较差、呼出气体中一氧化氮的数值较低（p N = 398），正在接受奥马珠单抗治疗，8.2%（N = 140）的患者依赖皮质类固醇（B 组为 10.6%）。B组接受抗白三烯药物治疗的患者比例最高（42.9%）：结论：65 岁以上成人的哮喘更为严重，并发症也更多，这表明需要对这些患者采取更综合、更多维度的哮喘治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asthma research and practice

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审稿时长

20 weeks

期刊介绍： Asthma Research and Practice is the official publication of Interasma and publishes cutting edge basic, clinical and translational research in addition to hot topic reviews and debate articles relevant to asthma and related disorders (such as rhinitis, COPD overlapping syndrome, sinusitis). The journal has a specialized section which focusses on pediatric asthma research. Asthma Research and Practice aims to serve as an international platform for the dissemination of research of interest to pulmonologists, allergologists, primary care physicians and family doctors, ENTs and other health care providers interested in asthma, its mechanisms and comorbidities.