The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends.

IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-04-08 DOI:10.1146/annurev-bioeng-060418-052547
Caroline A Murphy, Atul K Garg, Joana Silva-Correia, Rui L Reis, Joaquim M Oliveira, Maurice N Collins
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引用次数: 52

Abstract

The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Biomechanics of the meniscus are discussed in detail, as an understanding of the mechanics is fundamental for the development of new meniscal treatment strategies. Key meniscal characteristics such as biological function, damage (tears), and disease are critically analyzed. The latest technologies behind meniscal repair and regeneration are assessed.

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正常和骨关节炎组织中的半月板:面临结构特性挑战和当前治疗趋势。
半月板损伤的治疗最近正面临着向组织工程领域的范式转变,其目的是再生受损和患病的半月板,而不是目前的治疗技术。本文综述了与半月板相关的结构和力学。半月板是根据其生物结构和组成来定义的。详细讨论了半月板的生物力学,因为了解力学是发展新的半月板治疗策略的基础。关键的半月板特征,如生物功能,损伤(撕裂),和疾病进行严格的分析。评估了半月板修复和再生背后的最新技术。
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来源期刊
Annual Review of Biomedical Engineering
Annual Review of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
18.80
自引率
0.00%
发文量
14
期刊介绍: Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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