Dynamic regulation of hematopoietic stem cells by bone marrow niches.

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2018-09-01 Epub Date: 2018-08-02 DOI:10.1007/s40778-018-0132-x

Margot May, Anastasiya Slaughter, Daniel Lucas

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引用次数: 14

Abstract

Purpose of review: Hematopoietic stem cells (HSC) reside in a specialized microenvironment called the HSC niche. While key components of the niche have been known for several years, recent advances have identified several additional cell types that regulate HSC in the bone marrow (BM). Here we review our current understanding of the components and dynamics of the HSC niche.

Recent findings: While the niche has been considered a stable structure, recent advances clearly show that the niche is regulated in a dynamic manner to control HSC traffic and function. Moreover the niche can rapidly remodel in response to insults to the BM in a process controlled by positive and negative regulators.

Summary: Multiple niche cells have been shown to be dynamically regulated by systemic and local signals to influence how the niche controls HSC function. Elucidating how different components of the niche coordinate to orchestrate HSC behavior is essential to understand how the hematopoietic system adjusts blood cell production to the demands of the body.

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骨髓生态位对造血干细胞的动态调控。

综述目的:造血干细胞(HSC)存在于一个称为HSC生态位的特殊微环境中。虽然这个生态位的关键成分已经知道了几年，但最近的进展已经确定了几种调节骨髓中HSC的额外细胞类型(BM)。在这里，我们回顾了我们目前对HSC生态位的组成和动态的理解。最近的发现:虽然生态位被认为是一个稳定的结构，但最近的进展清楚地表明，生态位以一种动态的方式调节来控制HSC的流量和功能。此外，生态位可以在一个由正调节因子和负调节因子控制的过程中迅速重塑，以响应对BM的侮辱。摘要:多个生态位细胞受到系统和局部信号的动态调节，影响生态位如何控制HSC功能。阐明生态位的不同组成部分如何协调协调造血干细胞的行为，对于理解造血系统如何根据身体的需要调整血细胞生产是至关重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.