Tissue Destruction Caused by Entamoeba histolytica Parasite: Cell Death, Inflammation, Invasion, and the Gut Microbiome.

IF 3.1 Q2 MICROBIOLOGY Current Clinical Microbiology Reports Pub Date : 2019-01-01 Epub Date: 2019-01-21 DOI:10.1007/s40588-019-0113-6

Swagata Ghosh, Jay Padalia, Shannon Moonah

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引用次数: 41

Abstract

Purpose of review: Entamoeba histolytica is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. E. histolytica causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by E. histolytica.

Recent findings: Recent studies have identified new mechanisms involved in E. histolytica-induced tissue damage. These include (i) new form of contact-dependent killing called trogocytosis; (ii) parasite-produced cytokine, macrophage migration inhibitory factor, that contributes to inflammation; (iii) exploitation of host immune response to promote invasion; and (iv) the contribution of the gut microbiome to clinical disease.

Summary: Targeting these mechanisms that result in tissue injury should be a focus of future research for the development of improved preventive and therapeutic strategies for amebiasis.

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由溶组织内阿米巴原虫引起的组织破坏:细胞死亡、炎症、入侵和肠道微生物群。

综述目的:溶组织内阿米巴是一种引起阿米巴病的原生动物寄生虫，阿米巴病仍然是世界范围内发病率和死亡率的重要原因。溶组织芽胞杆菌引起组织破坏，从而导致临床疾病。这篇综述概述了一些最近的进展，这些进展进一步加深了我们对导致溶组织芽胞杆菌引起的组织损伤的过程的理解。最近的研究发现:最近的研究已经确定了肠溶菌诱导的组织损伤的新机制。这些包括:(i)称为穴道细胞病的新型接触依赖型杀伤;(ii)寄生虫产生的细胞因子，巨噬细胞迁移抑制因子，导致炎症;(iii)利用宿主免疫反应促进入侵;(四)肠道菌群对临床疾病的贡献。摘要:针对这些导致组织损伤的机制应该是未来研究的重点，以开发改进的阿米巴病预防和治疗策略。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.